{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:51:58Z","timestamp":1790398318592,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000147","name":"Canadian Breast Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Visual assessments of mammographic breast density by radiologists are used in clinical practice; however, these assessments have shown weaker associations with breast cancer risk than area-based, quantitative methods. The purpose of this study is to present a statistical evaluation of a fully automated, area-based mammographic density measurement algorithm. Five radiologists estimated density in 5% increments for 138 \u201cFor Presentation\u201d single MLO views; the median of the radiologists\u2019 estimates was used as the reference standard. Agreement amongst radiologists was excellent, ICC\u2009=\u20090.884, 95% CI (0.854, 0.910). Similarly, the agreement between the algorithm and the reference standard was excellent, ICC\u2009=\u20090.862, falling within the 95% CI of the radiologists\u2019 estimates. The Bland-Altman plot showed that the reference standard was slightly positively biased (+1.86%) compared to the algorithm-generated densities. A scatter plot showed that the algorithm moderately overestimated low densities and underestimated high densities. A box plot showed that 95% of the algorithm-generated assessments fell within one BI-RADS category of the reference standard. This study demonstrates the effective use of several statistical techniques that collectively produce a comprehensive evaluation of the algorithm and its potential to provide mammographic density measures that can be used to inform clinical practice.<\/jats:p>","DOI":"10.1155\/2013\/651091","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T17:35:51Z","timestamp":1368034551000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Statistical Evaluation of a Fully Automated Mammographic Breast Density Algorithm"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1892-9961","authenticated-orcid":true,"given":"Mohamed","family":"Abdolell","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada B3H 2Y9"},{"name":"Department of Diagnostic Imaging, Capital District Health Authority, Halifax, NS, Canada B3H 2Y9"},{"name":"Division of Medical Education\/Informatics, Dalhousie University, Halifax, NS, Canada B3H 2Y9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-6237","authenticated-orcid":true,"given":"Kaitlyn","family":"Tsuruda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Capital District Health Authority, Halifax, NS, Canada B3H 2Y9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada B3H 2Y9"},{"name":"Department of Diagnostic Imaging, Capital District Health Authority, Halifax, NS, Canada B3H 2Y9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3193-176X","authenticated-orcid":true,"given":"Judy","family":"Caines","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada B3H 2Y9"},{"name":"Department of Diagnostic Imaging, Capital District Health Authority, Halifax, NS, Canada B3H 2Y9"},{"name":"Nova Scotia Breast Screening Program, Halifax, NS, Canada B3H 2Y9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"issue":"8","key":"2","first-page":"728","volume":"12","year":"2003","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/1097-0142(197605)37:5<2486::AID-CNCR2820370542>3.0.CO;2-8","volume":"37","year":"1976","journal-title":"Cancer"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(96)01138-2"},{"issue":"15","key":"6","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/jnci\/84.15.1170","volume":"84","year":"1992","journal-title":"Journal of the National Cancer Institute"},{"key":"7","year":"1993"},{"key":"8","volume":"10","year":"2010","journal-title":"BMC cancer"},{"issue":"9","key":"10","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/jnci\/87.9.670","volume":"87","year":"1995","journal-title":"Journal of the National Cancer Institute"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0107"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/11\/003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2102"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-13666-5_51"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2634"},{"issue":"8476","key":"18","first-page":"307","volume":"1","year":"1986","journal-title":"The Lancet"},{"issue":"2","key":"19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/00220345860650020701","volume":"65","year":"1986","journal-title":"Journal of Dental Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0976-y"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0734-189X(85)90125-2","volume":"29","year":"1985","journal-title":"Computer Vision, Graphics, & Image Processing"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0734-189X(85)90133-1","volume":"29","year":"1985","journal-title":"Computer Vision, Graphics, & Image Processing"},{"key":"24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/001316447303300309","volume":"33","year":"1973","journal-title":"Educational and Psychological Measurement"},{"issue":"1","key":"25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","volume":"33","year":"1977","journal-title":"Biometrics"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301020870"},{"issue":"8476","key":"27","first-page":"307","volume":"1","year":"1986","journal-title":"The Lancet"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2013\/651091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2013\/651091.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2013\/651091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T08:44:08Z","timestamp":1498034648000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2013\/651091\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"alternative-id":["651091","651091"],"URL":"https:\/\/doi.org\/10.1155\/2013\/651091","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}