{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:45:48Z","timestamp":1788965148235,"version":"build-2803163510"},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Microcystic variant of urothelial carcinoma is one of the new variants of urothelial carcinoma that was added to the WHO classification in 2004.<jats:italic>Aims.<\/jats:italic>To review the literature on microcystic variant of urothelial carcinoma.<jats:italic>Methods.<\/jats:italic>Various internet search engines were used to identify reported cases of the tumour.<jats:italic>Results<\/jats:italic>. Microscopic features of the tumour include: (i) Conspicuous intracellular and intercellular lumina\/microcysts encompassed by malignant urothelial or squamous cells. (ii) The lumina are usually empty; may contain granular eosinophilic debris, mucin, or necrotic cells. (iii) The cysts may be variable in size; round, or oval, up to 2\u2009mm; lined by urothelium which are either flattened cells or low columnar cells however, they do not contain colonic epithelium or goblet cells; are infiltrative; invade the muscularis propria; mimic cystitis cystica and cystitis glandularis; occasionally exhibit neuroendocrine differentiation. (iv) Elongated and irregular branching spaces are usually seen. About 17 cases of the tumour have been reported with only 2 patients who have survived. The tumour tends to be of high-grade and high-stage. There is no consensus opinion on the best option of treatment of the tumour.<jats:italic>Conclusions<\/jats:italic>. It would prove difficult at the moment to be dogmatic regarding its prognosis but it is a highly aggressive tumour. New cases of the tumour should be reported in order to document its biological behaviour.<\/jats:p>","DOI":"10.1155\/2013\/654751","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T21:01:44Z","timestamp":1386018104000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Microcystic Variant of Urothelial Carcinoma"],"prefix":"10.1155","volume":"2013","author":[{"given":"Anthony Kodzo-Grey","family":"Venyo","sequence":"first","affiliation":[{"name":"North Manchester General Hospital, Department of Urology, Delaunays Road, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","series-title":"AFIP Atlas of Tumor Pathology Series","volume":"1","year":"2004"},{"key":"2","year":"2004"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1046\/j.1464-410X.1997.00123.x","volume":"79","year":"1997","journal-title":"British Journal of Urology"},{"issue":"5","key":"5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/ajcp\/96.5.635","volume":"96","year":"1991","journal-title":"American Journal of Clinical Pathology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0693-7"},{"key":"7","year":"2012"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90395-J"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.12.005"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-3-36"},{"issue":"7","key":"11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.5858\/2002-126-0859-MTCC","volume":"126","year":"2002","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1159\/000115382"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02893496","volume":"13","year":"2007","journal-title":"Pathology and Oncology Research"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90003-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-004-7968-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-4-90"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050892"}],"container-title":["Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2013\/654751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2013\/654751.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2013\/654751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:17:34Z","timestamp":1647605854000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/au\/2013\/654751\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":16,"alternative-id":["654751","654751"],"URL":"https:\/\/doi.org\/10.1155\/2013\/654751","relation":{},"ISSN":["1687-6369","1687-6377"],"issn-type":[{"value":"1687-6369","type":"print"},{"value":"1687-6377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}