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Pretreatment with both<jats:italic>H. inuloides<\/jats:italic>extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>-globulin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>-GLOB) and albumin (ALB) observed in CCl<jats:sub>4<\/jats:sub>-induced tissue injury. The protective effect was confirmed by histological analysis with hematoxylin-eosin and periodic acid\/Schiff's reagent. Level of lipid peroxidation was higher in the organs of rats exposed to CCl<jats:sub>4<\/jats:sub>than in those of the animals treated with<jats:italic>Heterohteca<\/jats:italic>extracts or quercetin, and these showed levels similar to the untreated group. Pretreatment of animals with either of the extracts or quercetin also prevented the increase of 4-hydroxynonenal and 3-nitrotyrosine. Pretreatment with the plant extracts or quercetin attenuated CCl<jats:sub>4<\/jats:sub>toxic effects on the activity of several antioxidant enzymes. The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCl<jats:sub>4<\/jats:sub>toxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue.<\/jats:p>","DOI":"10.1155\/2013\/659165","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T21:28:20Z","timestamp":1357853300000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Acetonic and Methanolic Extracts of<i>Heterotheca inuloides<\/i>, and Quercetin, Decrease CCl<sub>4<\/sub>-Oxidative Stress in Several Rat Tissues"],"prefix":"10.1155","volume":"2013","author":[{"given":"Elvia","family":"Coballase-Urrutia","sequence":"first","affiliation":[{"name":"Laboratorio de Neuroqu\u00edmica, Instituto Nacional de Pediatr\u00eda, Insurgentes Sur 3700-C, 04530 M\u00e9xico, DF, 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