{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:30:30Z","timestamp":1788870630791,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005742","name":"Universidade Federal de Goi\u00e1s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Pimenta pseudocaryophyllus<\/jats:italic>\n                    popularly referred to as craveiro is considered as a calming agent in different local preparations. The present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase (MAO), tryptophan, and tyrosine hydroxylase. Based on the research focus, tail suspension (TS), forced swimming (FS), and open field (OF) tests were conducted after oral administration of DF (125, 250, or 500\u2009mg\/Kg). Ex vivo assay of MAO was also conducted to evaluate inhibitory effect of DF (250\u2009mg\/Kg). Administration of DF elicits antidepressant-like response in the TS and FS. However, DF 500\u2009mg\/Kg did not alter mice performance in these models. The data obtained in the OF showed a reduction in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance. Mice pretreatment with p-chlorophenylalanine methyl ester (PCPA) (100\u2009mg\/kg, i.p.\u2014serotonin biosynthesis inhibitor) for 4 consecutive days or acute administration of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -methyl-p-tyrosine (AMPT) (100\u2009mg\/kg, i.p.\u2014catecholamine synthesis inhibitor) blocked anti-immobility effect of DF in the FS. In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO. Our findings support antidepressant-like activity of DF and suggest an effect that depends on monoamine biosynthesis.\n                  <\/jats:p>","DOI":"10.1155\/2013\/659391","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:58:45Z","timestamp":1357757925000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Antidepressive-Like Property of Dichloromethane Fraction of\n                    <i>Pimenta pseudocaryophyllus<\/i>\n                    and Relevance of Monoamine Metabolic Enzymes"],"prefix":"10.1155","volume":"2013","author":[{"given":"James Oluwagbamigbe","family":"Fajemiroye","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Federal University of Goi\u00e1s, Campus Samambaia, 74001-970 Goi\u00e2ania, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds Rodrigues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department 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