{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:46:11Z","timestamp":1756809971141,"version":"3.37.3"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["7050098"],"award-info":[{"award-number":["7050098"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Chinese herbal medicine (CHM) has been widely used as an adjunct to western medicine in treating angina in China. We carried out this systematic review to evaluate the effectiveness of CHM on top of western medicine for angina. This meta-analysis included 46 randomized control trials with 4212 patients. For trials that included stable angina patients, the CHM group had significant lower incidence of total heart events (relative risk<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mtext>RR<\/mml:mtext><mml:mo stretchy=\"false\">)<\/mml:mo><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.50<\/mml:mn><\/mml:math>, 95% confidence interval (CI) 0.33\u20130.78), myocardial infarction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.32<\/mml:mn><\/mml:math>, 95% CI 0.14\u20130.72), heart failure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.37<\/mml:mn><\/mml:math>, 95% CI 0.15\u20130.91), and angina (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.46<\/mml:mn><\/mml:math>, 95% CI 0.30\u20130.71) than that of control group. For trials that included unstable angina patients, CHM led to significantly lower occurrence of total heart events (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.46<\/mml:mn><\/mml:math>, 95% CI 0.32\u20130.66), myocardial infarction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.37<\/mml:mn><\/mml:math>, 95% CI 0.26\u20130.54), and angina (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.36<\/mml:mn><\/mml:math>, 95%CI 0.26\u20130.51). Likewise, for trials that included stable or unstable angina patients, the rates of myocardial infarction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.34<\/mml:mn><\/mml:math>, 95% CI 0.17\u20130.68) and angina (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mtext>RR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.46<\/mml:mn><\/mml:math>, 95% CI 0.30\u20130.70) in CHM group were significantly lower than that in control group. In conclusion, CHM is very likely to be able to improve the survival of angina patients who are already receiving western medicine.<\/jats:p>","DOI":"10.1155\/2013\/673193","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T16:03:27Z","timestamp":1386864207000},"page":"1-15","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Add-On Effect of Chinese Patent Medicine for Patients with Stable or Unstable Angina: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Chen","family":"Mao","sequence":"first","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent C. H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Qiu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu-Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yin","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ling","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, 4\/F School of Public Health Building, Shatin, New Territories, Hong Kong"},{"name":"Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, 10 Yuexing Erdao, Nanshan District, Shenzhen, Guangdong 518000, China"},{"name":"The Hong Kong Branch of the Chinese Cochrane Centre, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301436"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.204511"},{"issue":"7499","key":"3","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/bmj.330.7499.1046","volume":"330","year":"2005","journal-title":"British Medical Journal"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.720953"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.090894"},{"issue":"11","key":"6","first-page":"S358","volume":"10","year":"2004","journal-title":"The American Journal of Managed Care"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020688.24874.90"},{"issue":"7","key":"8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2012.06.004","volume":"60","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61354-9"},{"issue":"8","key":"10","first-page":"587","volume":"23","year":"2003","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"1","key":"11","first-page":"124","volume":"1","year":"1985","journal-title":"Chinese Medicine Pharmacology and Clinical Practice"},{"issue":"7","key":"12","first-page":"92","volume":"23","year":"2009","journal-title":"Chinese Primary Health Care"},{"issue":"1","key":"13","first-page":"92","volume":"18","year":"2008","journal-title":"Clinical Journal of Hemorrhage"},{"issue":"34","key":"14","first-page":"147","volume":"6","year":"2009","journal-title":"China Medical Herald"},{"issue":"23","key":"15","first-page":"82","volume":"5","year":"2010","journal-title":"China Practical Medicine"},{"year":"2011","key":"16"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"issue":"12","key":"18","first-page":"24","volume":"12","year":"1996","journal-title":"Shanghai Medicine"},{"issue":"4","key":"19","first-page":"263","volume":"5","year":"2003","journal-title":"Journal of Liaoning College of Traditional Chinese Medicine"},{"issue":"11","key":"20","first-page":"11","volume":"6","year":"2003","journal-title":"Heilongjiang Medicine"},{"issue":"2","key":"21","first-page":"181","volume":"15","year":"2006","journal-title":"Chinese Journal of Cardiovascular Rehabilitation Medicine"},{"issue":"11","key":"22","first-page":"81","volume":"34","year":"2007","journal-title":"Central Plains Medical Journal"},{"issue":"9","key":"23","volume":"5","year":"2007","journal-title":"Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease"},{"issue":"7","key":"24","first-page":"1081","volume":"29","year":"2008","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"7","key":"25","first-page":"1081","volume":"29","year":"2008","journal-title":"Guangdong Medical Journal"},{"issue":"24","key":"26","first-page":"40","volume":"16","year":"2009","journal-title":"China Modern Medicine"},{"issue":"5","key":"27","first-page":"270","volume":"7","year":"2000","journal-title":"Chinese Journal of Integrative Traditional and Western Medicine in Intensive and Critical Care"},{"issue":"5","key":"28","volume":"19","year":"2001","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"issue":"4","key":"29","first-page":"270","volume":"14","year":"2001","journal-title":"The Journal of Practical Medicine"},{"issue":"2","key":"30","first-page":"90","volume":"29","year":"2002","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"6","key":"31","first-page":"620","volume":"15","year":"2002","journal-title":"Chinese Journal of the Practical Chinese With Modern Medicine"},{"issue":"9","key":"32","first-page":"998","volume":"23","year":"2002","journal-title":"Journal of Qiqihar University of Medicine"},{"issue":"2","key":"33","first-page":"99","volume":"12","year":"2003","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"issue":"1","key":"34","first-page":"3","volume":"12","year":"2003","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"4","key":"35","first-page":"244","volume":"1","year":"2003","journal-title":"Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease"},{"issue":"6","key":"36","first-page":"3","volume":"3","year":"2003","journal-title":"Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"12","key":"37","first-page":"797","volume":"13","year":"2004","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"issue":"7","key":"38","first-page":"378","volume":"48","year":"2005","journal-title":"People\u2019s Military Surgeon"},{"issue":"9","key":"39","first-page":"1288","volume":"18","year":"2005","journal-title":"Chinese Journal of the Practical Chinese with Modern Medical"},{"issue":"8","key":"40","first-page":"701","volume":"18","year":"2006","journal-title":"Medical Journal of ChineSe People\u2019S Health"},{"issue":"10","key":"41","first-page":"746","volume":"17","year":"2006","journal-title":"Medical Journal of the Chinese People\u2019s Armed Police Forces"},{"key":"42","first-page":"195","volume":"18","year":"2007","journal-title":"Chinese Journal of Scientific and Technical Periodicals"},{"key":"43","first-page":"97","volume":"45","year":"2007","journal-title":"China Modern Doctor"},{"key":"44","first-page":"806","volume":"5","year":"2007","journal-title":"Chinese Journal of Integrated Medicine on Cardio\/Cerebrovascular Disease"},{"key":"45","first-page":"605","volume":"34","year":"2007","journal-title":"Liao Ning Journal of Traditional Chinese Medicine"},{"key":"46","first-page":"831","volume":"3","year":"2008","journal-title":"Internal Medicine of China"},{"key":"47","first-page":"90","volume":"35","year":"2008","journal-title":"Central Plains Medical Journal"},{"key":"48","first-page":"2209","volume":"26","year":"2008","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"49","first-page":"102","volume":"5","year":"2008","journal-title":"China Medical Herald"},{"issue":"5","key":"50","first-page":"441","volume":"6","year":"2008","journal-title":"Chinese Medicine Modern Distance Education of China"},{"issue":"32","key":"51","first-page":"3959","volume":"18","year":"2009","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"22","key":"52","first-page":"40","volume":"18","year":"2009","journal-title":"Chinese Journal of Ethnomedicine and Ethnopharmacy"},{"issue":"3","key":"53","first-page":"247","volume":"50","year":"2009","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"25","key":"54","first-page":"6123","volume":"9","year":"2009","journal-title":"Chinese Journal of Misdiagnostics"},{"issue":"19","key":"55","first-page":"2261","volume":"18","year":"2009","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"13","key":"56","first-page":"104","volume":"16","year":"2009","journal-title":"China Modern Medicine"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-010-0013-3"},{"issue":"2","key":"58","first-page":"114","volume":"118","year":"2005","journal-title":"Journal of Handan Medical College"},{"issue":"12","key":"59","first-page":"1658","volume":"17","year":"2008","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"issue":"12","key":"60","first-page":"1985","volume":"23","year":"2008","journal-title":"Guangming Journal of Chinese Medicine"},{"issue":"6","key":"61","first-page":"649","volume":"7","year":"2009","journal-title":"Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease"},{"issue":"4","key":"62","first-page":"61","volume":"27","year":"2009","journal-title":"Journal of Sichuan of Traditional Chinese Medicine"},{"issue":"7","key":"63","first-page":"52","volume":"7","year":"2010","journal-title":"China Medical Herald"},{"volume":"2012","journal-title":"Evidence-Based Complementary and Alternative Medicine","year":"2012","key":"64"},{"issue":"2","key":"65","first-page":"37","volume":"22","year":"2008","journal-title":"Guangming Journal of Chinese Medicine"},{"issue":"4","key":"66","first-page":"383","volume":"26","year":"2007","journal-title":"Herald of Medicine"},{"issue":"4","key":"67","first-page":"317","volume":"5","year":"2005","journal-title":"Chinese Journal of Evidence-Based Medicine"},{"issue":"8","key":"68","first-page":"919","volume":"11","year":"2011","journal-title":"Chinese Journal of Evidence-Based Medicine"},{"journal-title":"Cochrane Database of Systematic Reviews","issue":"4","year":"2006","key":"69"},{"issue":"18","key":"70","first-page":"2231","volume":"19","year":"2010","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"44","key":"71","first-page":"4143","volume":"21","year":"2010","journal-title":"China Pharmacy"},{"issue":"11","key":"72","first-page":"216","volume":"12","year":"2010","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine Pharmacology and Clinical Practice"},{"issue":"1","key":"73","first-page":"RA1","volume":"14","year":"2008","journal-title":"Medical Science Monitor"},{"issue":"6","key":"74","first-page":"334","volume":"10","year":"2007","journal-title":"Practical Pharmacy and Clinical Remedies"},{"issue":"7650","key":"75","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","year":"2008","journal-title":"British Medical Journal"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/673193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/673193.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/673193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:09:57Z","timestamp":1498090197000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/673193\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":75,"alternative-id":["673193","673193"],"URL":"https:\/\/doi.org\/10.1155\/2013\/673193","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2013]]}}}