{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:40:15Z","timestamp":1773355215088,"version":"3.50.1"},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological Sciences"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Nefang<\/jats:italic>is a polyherbal product composed of<jats:italic>Mangifera indica<\/jats:italic>(bark and leaf),<jats:italic>Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum<\/jats:italic>(leaves), used for the treatment of malaria. Compounds with antioxidant activity are believed to modulate plasmodial infection. Antioxidant activity of the constituent aqueous plants extracts,<jats:italic>in vitro<\/jats:italic>, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and,<jats:italic>in vivo<\/jats:italic>,<jats:italic>Nefang<\/jats:italic>(100 and 500\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats. Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out.<jats:italic>P. guajava, M. indica<\/jats:italic>leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference. Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with<jats:italic>Nefang<\/jats:italic>showed increased levels in the former and dose-dependent decrease towards normal levels in the later. These results reveal the constituent plants of<jats:italic>Nefang<\/jats:italic>that contribute to its<jats:italic>in vivo<\/jats:italic>antioxidant potential. This activity is a good indication of the therapeutic potential of<jats:italic>Nefang<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2013\/678458","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T21:03:36Z","timestamp":1387487016000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value"],"prefix":"10.1155","volume":"2013","author":[{"given":"Protus","family":"Arrey Tarkang","sequence":"first","affiliation":[{"name":"Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaound\u00e9, Cameroon"},{"name":"Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille Parfait","family":"Nwachiban Atchan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules-Roger","family":"Kuiate","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith Apoelot","family":"Okalebo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia Nkatha","family":"Guantai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacognosy, University of Nairobi, P.O. 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