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An increased understanding of the corneal sensitivity and dry eye disease in keratoconus, including alterations of the conjunctival cells, may help explain the pathogenesis of this disorder. There is histological evidence of the involvement of corneal nerves in the pathology of keratoconus and it has been suggested that this plays a role in the pathophysiological features and progression of the disease. In this review, the impaired corneal sensitivity found on keratoconus and corneal sensitivity changes after cross\u2010linking performed in patients with keratoconus are reported.<\/jats:p>","DOI":"10.1155\/2013\/683090","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T03:09:46Z","timestamp":1383275386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Corneal Sensitivity in Keratoconus: A Review of the Literature"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-3956","authenticated-orcid":false,"given":"Leopoldo","family":"Spadea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-5866","authenticated-orcid":false,"given":"Enzo Maria","family":"Vingolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374203-2.00068-3"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.12.010"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90094-8"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.042"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90817-2"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.01.091"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_2_9_8_2","unstructured":"Eye Banking Statistical Report Eye Bank Association of America Web site 2011 http:\/\/www.restoresight.org\/."},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.04.031"},{"key":"e_1_2_9_10_2","first-page":"1117","article-title":"Expression of degradative enzymes and protease inhibitors in corneas with keratoconus","volume":"39","author":"Zhou L.","year":"1998","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1076\/0271-3683(200008)2121-VFT662"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.00448.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.04.006"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2012.05.029"},{"key":"e_1_2_9_15_2","first-page":"68","article-title":"Observations on the innervation of the cornea","volume":"85","author":"Zander E.","year":"1951","journal-title":"Journal of Anatomy"},{"key":"e_1_2_9_16_2","first-page":"476","article-title":"Ultrastructural organization of human corneal nerves","volume":"37","author":"M\u00fcller L. 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