{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:51:41Z","timestamp":1776541901705,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Trimetazidine (TMZ) has been used as an anti\u2010ischemic agent for angina pectoris, chorioretinal disturbances, and vertigo. Also, it can induce extrapyramidal type adverse reaction such as parkinsonism, gait disorder, and tremor via blockade of D2 receptors. In the present study, we evaluated the effect of TMZ on novelty\u2010induced rearing behavior and apomorphine\u2010induced stereotypy behavior in male rats. Four groups of rat (<jats:italic>n<\/jats:italic> = 7) were administrated with TMZ (10 and 20\u2009mg\/kg, i.p.), chlorpromazine (1\u2009mg\/kg, i.p.), or isotonic saline. One hour later, apomorphine (2\u2009mg\/kg, s.c.) was administrated to each rat. Our results showed that both doses of TMZ significantly decreased the rearing behavior in rats, whereas the decrease with chlorpromazine was higher. TMZ also decreased the stereotypy scores in a dose\u2010dependent manner. We concluded that TMZ has beneficial effects on rearing behavior and stereotypy, which are accepted to be indicators of antipsychotic effect. Taken together, with its antioxidative and cytoprotective properties, TMZ is worthy of being investigated for its anti\u2010psychotic effects as a primary or an adjunctive drug.<\/jats:p>","DOI":"10.1155\/2013\/686304","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T21:44:57Z","timestamp":1382478297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antipsychotic\u2010Like Effect of Trimetazidine in a Rodent Model"],"prefix":"10.1155","volume":"2013","author":[{"given":"Oytun","family":"Erba\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin Serdar","family":"Akseki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Elik\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Ta\u015fk\u0131ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890010203"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-25761-2_1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858403252674"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204700106"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.360"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02015.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.088"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00717.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.07.001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V38N5p396"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199407000-00008"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1074248409356431"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80461-5"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0826-z"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018899802836"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02125756"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003950050026"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5730-8_58"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199312000-00008"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.01008.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23828"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.2515\/therapie:2005061"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.63"},{"key":"e_1_2_7_24_2","first-page":"287","article-title":"Possible evidence of angiotensin II and endogenous opioid modulation of novelty-induced rearing in the rat","volume":"23","author":"Ajayi A. A.","year":"1994","journal-title":"African Journal of Medicine and Medical Sciences"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702350"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2009.13.2.71"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.10.003"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.06.026"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.03.008"},{"key":"e_1_2_7_30_2","volume-title":"Stahl\u2032s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications","author":"Stahl S. M.","year":"2000"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00147-X"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00035-6"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<168::AID-SYN2>3.0.CO;2-B"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00347-0"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.07.003"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71031002.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.09.032"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17.2.227"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.11.009"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0117-1"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200102000-00015"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n1107"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990654"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/686304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/686304.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2013\/686304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T14:30:47Z","timestamp":1720276247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2013\/686304"}},"subtitle":[],"editor":[{"given":"N.","family":"Berretta","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"J. L.","family":"Labandeira-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"A.","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Y.","family":"Yoshiyama","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1155\/2013\/686304"],"URL":"https:\/\/doi.org\/10.1155\/2013\/686304","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2013-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"686304"}}