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We investigated the impact of induction of labor upon placental autophagy, a catabolic pathway activated in response to alteration of the physiological intracellular conditions. We collected 28 singleton placentas at the time of uncomplicated term vaginal delivery (7 spontaneous onset of labor, 21 induced labor). Autophagy was evaluated by immunohistochemistry, immunofluorescence, and immunoblotting. No significant difference in the autophagy expression was found between spontaneous or induced onset of labor. We found an inverse relationship between autophagy expression and the maternal prepregnancy body mass index, irrespective of the mode of labor onset. This result could be related to the nutritional maternal habits before and throughout pregnancy rather than rapid metabolic changes during labor.<\/jats:p>","DOI":"10.1155\/2013\/689768","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T21:03:33Z","timestamp":1374008613000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Autophagy and Human Parturition: Evaluation of LC3 Expression in Placenta from Spontaneous or Medically Induced Onset of Labor"],"prefix":"10.1155","volume":"2013","author":[{"given":"Laura","family":"Avagliano","sequence":"first","affiliation":[{"name":"Unit of Obstetrics and Gynecology, Department of Health Sciences, San Paolo Hospital Medical School, University of Milan, Via A. di Rudin\u00ec 8, 20142 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Virgili","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Laboratories, 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