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BPA was subcutaneously injected into mice at a dose of 20\u2009mg\/kg body weight (BW) for 7 consecutive days. LBP was administered simultaneously with BPA by gavage daily at the dose of 50, 100, and 200\u2009mg\/kg BW for 7 days. After treatment, the weight and the histopathology changes of testis and epididymis were examined; the contents of T, LH, GnRH, antioxidant enzyme, and malondialdehyde (MDA) in serum were detected; proapoptotic protein Bax and antiapoptotic protein Bcl-2 were also detected by immunohistochemical method. Results showed that the weights of testis and epididymis were all increased after supplement with different dosages of LBP compared with BPA group, and the activities of SOD and GSH-Px were significantly increased in LBP groups, while MDA contents were gradually decreased. Moreover, the levels of T, LH, and GnRH were significantly elevated in serum treated with 100\u2009mg\/kg LBP. LBP also shows significant positive effects on the expression of Bcl-2\/Bax in BPA treated mice. It is concluded that LBP may be one of the potential ingredients protecting the adult male animals from BPA induced reproductive damage.<\/jats:p>","DOI":"10.1155\/2013\/690808","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T16:01:24Z","timestamp":1388073684000},"page":"1-9","source":"Crossref","is-referenced-by-count":26,"title":["Protective Effects of<i>Lycium barbarum<\/i>Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-7031","authenticated-orcid":true,"given":"Caili","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Veterinary Medicine, 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