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In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T\/T wild type, T\/G heterozygote, and G\/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies.<\/jats:p>","DOI":"10.1155\/2013\/695918","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T16:34:53Z","timestamp":1383669293000},"page":"669-672","source":"Crossref","is-referenced-by-count":11,"title":["High Frequency of a Single Nucleotide Substitution (c.-6-180T&gt;G) of the Canine<i>MDR1\/ABCB1<\/i>Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs"],"prefix":"10.1155","volume":"35","author":[{"given":"Keijiro","family":"Mizukami","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, 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