{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:58:29Z","timestamp":1792004309969,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"\u00c7ukurova University in Adana, Turkey"},{"name":"Gazi University in Ankara, Turkey"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013]]},"abstract":"\n Objective<\/jats:italic>\n .\n Candida krusei<\/jats:italic>\n causes approximately 1% of vulvovaginal candidiasis (VVC) cases and is naturally resistant to fluconazole. Antifungal testing may be required if\n C. krusei<\/jats:italic>\n vaginitis fails to respond to non-fluconazole therapy, particularly in patients with recurrent infections.\n Design<\/jats:italic>\n . We investigated the clinical characteristics and antifungal susceptibility profile of vaginal\n C. krusei<\/jats:italic>\n isolates. Between 2009 and 2012, we identified 560 unrelated\n Candida<\/jats:italic>\n spp.-positive vaginal cultures, of which 28 (5.0%) were\n C. krusei<\/jats:italic>\n . These isolates were analyzed according to host factors and the clinical forms of VVC, and their\n in vitro<\/jats:italic>\n susceptibility to 10 antifungal agents was tested using a reference microdilution method.\n Results<\/jats:italic>\n . We observed that perineal laceration and increased age (>50 years) were significant predictors of\n C. krusei<\/jats:italic>\n in vaginal samples (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.05<\/mml:mn>\n <\/mml:math>\n ). All isolates were susceptible to amphotericin B, caspofungin, ketoconazole, and miconazole. Additionally, susceptible dose-dependent and resistant rates were found for fluconazole as 42.9% and 57.1%, respectively. Remarkably, only 42.9% and 67.9% of the isolates were susceptible to itraconazole and voriconazole, respectively.\n Conclusions<\/jats:italic>\n . Understanding local susceptibility patterns, especially those of non-\n C. albicans Candida<\/jats:italic>\n species, can significantly aid in the selection of an effective antifungal agent. The\n in vivo<\/jats:italic>\n response of\n C. krusei<\/jats:italic>\n vaginitis to various antifungal therapeutics remains unknown and requires further research.\n <\/jats:p>","DOI":"10.1155\/2013\/698736","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T16:02:43Z","timestamp":1386777763000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Clinical Characteristics of Turkish Women with\n Candida krusei<\/i>\n Vaginitis and Antifungal Susceptibility of the\n C. krusei<\/i>\n Isolates"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ahmet Bari\u015f","family":"G\u00fczel","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of \u00c7ukurova, 01330 Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Gazi, 06500 Ankara, Turkey"},{"name":"Department of Microbiology, Faculty of Medicine, University of Erzincan, 24000 Erzincan, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melda","family":"Meral","sequence":"additional","affiliation":[{"name":"Division of Mycology, Department of Microbiology, Faculty of Medicine, University of \u00c7ukurova, 01330 Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Kalkanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Gazi, 06500 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-9759","authenticated-orcid":true,"given":"Macit","family":"Ilkit","sequence":"additional","affiliation":[{"name":"Division of Mycology, Department of Microbiology, Faculty of Medicine, University of \u00c7ukurova, 01330 Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2011.576332"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00289-X"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.497972"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90347-X"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1086\/343826"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/10647440400025603"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01915-07"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.34-38.2003"},{"issue":"10","key":"10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/jcp.44.10.826","volume":"44","year":"1991","journal-title":"Journal of Clinical Pathology"},{"key":"11","first-page":"97","volume-title":"Identification of yeasts","year":"1989"},{"key":"12","year":"2008"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/13693786.2012.662597","volume":"50","year":"2012","journal-title":"Medical Mycology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.09.002"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/AOG.0b013e31827307b2","volume":"120","year":"2012","journal-title":"Obstetrics & Gynecology"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2155-2162.2005"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02363-09"}],"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2013\/698736.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2013\/698736.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2013\/698736.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:06:06Z","timestamp":1498089966000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/idog\/2013\/698736\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":17,"alternative-id":["698736","698736"],"URL":"https:\/\/doi.org\/10.1155\/2013\/698736","relation":{},"ISSN":["1064-7449","1098-0997"],"issn-type":[{"value":"1064-7449","type":"print"},{"value":"1098-0997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}