{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:09Z","timestamp":1740164589811,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>This case report describes a patient with an idiopathic acquired Factor VIII inhibitor and severe bleeding. She was treated with rituximab after failing first-line treatment with steroids and cyclophosphamide. Two months following rituximab treatment, our patient developed a succession of severe opportunistic infections requiring intensive care unit admission. Over a period of 12 weeks she required treatment for<jats:italic>Pseudomonas aeruginosa<\/jats:italic>septicaemia, herpes simplex gingivostomatitis and pharyngotonsillitis, clostridium difficile-related diarrhoea, systemic cytomegalovirus infection, pneumocystis jiroveci, and invasive pulmonary aspergillosis lung infections. After significant rehabilitation, the patient was finally discharged following a 5-month admission. This case highlights the complexity of balancing a life-threatening condition with the side effects of treatment. It also raises the issue of routine prophylaxis for immunosuppression in nonmalignant conditions, which will become a common dilemma with the expanding indications for rituximab use.<\/jats:p>","DOI":"10.1155\/2013\/703027","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T21:59:45Z","timestamp":1387403985000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["A Case of an Acquired Factor VIII Inhibitor Complicated by Multiple Treatment-Related Opportunistic Infections and Review of the Literature"],"prefix":"10.1155","volume":"2013","author":[{"given":"Anna L.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-5068","authenticated-orcid":true,"given":"Yi Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-0890","authenticated-orcid":true,"given":"Giselle","family":"Kidson-Gerber","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of New South Wales, Botany Street, Sydney, NSW 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143586"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0038-1650169","volume":"45","year":"1981","journal-title":"Thrombosis and Haemostasis"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0968-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328309ecab"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01342.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10553"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00669.x"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1182\/blood.V86.2.797.bloodjournal862797","volume":"86","year":"1995","journal-title":"Blood"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0765"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.017749"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1177\/1076029607303777"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500473113"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl393"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701411441"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02785.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.004"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-008-9049-z"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08076.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/art.23059"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/703027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/703027.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/703027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T12:42:39Z","timestamp":1597236159000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2013\/703027\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"alternative-id":["703027","703027"],"URL":"https:\/\/doi.org\/10.1155\/2013\/703027","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2013]]}}}