{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:34:15Z","timestamp":1784900055258,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. In this study we retrospectively evaluated if<jats:sup>18<\/jats:sup>F-FDG-PET\/CT provided incremental diagnostic information over CI in a group of hepatoblastoma patients performing restaging.<jats:italic>Procedure<\/jats:italic>. Nine patients (mean age: 5.9\u2009years; range: 3.1\u201312\u2009years) surgically treated for hepatoblastoma were followed up by clinical examination, serum<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-FP monitoring, and US. CI (CT or MRI) and PET\/CT were performed in case of suspicion of relapse. Fine-needle aspiration biopsies (FNAB) were carried out for final confirmation if the results of CI, PET\/CT, and\/or<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-FP levels were suggestive of relapse. PET\/CT and CI findings were analyzed for comparison purposes, using FNAB as reference standard.<jats:italic>Results<\/jats:italic>.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-FP level was suggestive of disease recurrence in 8\/9 patients. Biopsy was performed in 8\/9\u2009cases. CI and PET\/CT resulted to be concordant in 5\/9 patients (CI identified recurrence of disease, but<jats:sup>18<\/jats:sup>F-FDG-PET\/CT provided a better definition of disease extent); in 4\/9 cases, CI diagnostic information resulted in negative findings, whereas PET\/CT correctly detected recurrence of disease.<jats:sup>18<\/jats:sup>F-FDG-PET\/CT showed an agreement of 100% (8\/8) with FNAB results.<jats:italic>Conclusions<\/jats:italic>.<jats:sup>18<\/jats:sup>F-FDG-PET\/CT scan seems to better assess HB patients with respect to CI and may provide incremental diagnostic value in the restaging of this group of patients.<\/jats:p>","DOI":"10.1155\/2013\/709037","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T17:01:02Z","timestamp":1377536462000},"page":"1-6","source":"Crossref","is-referenced-by-count":19,"title":["A Comparison between<sup><b>18<\/b><\/sup>F-FDG PET\/CT Imaging and Biological and Radiological Findings in Restaging of 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