{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:39:50Z","timestamp":1740137990539,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["482113\/2010-3"],"award-info":[{"award-number":["482113\/2010-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process.<jats:italic>Objective<\/jats:italic>. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis.<jats:italic>Methods<\/jats:italic>. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry.<jats:italic>Results<\/jats:italic>. The frequency of CD4<jats:sup>+<\/jats:sup>CD28<jats:sup>+<\/jats:sup>T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4<jats:sup>+<\/jats:sup>T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8<jats:sup>+<\/jats:sup>T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8<jats:sup>+<\/jats:sup>T cells, CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>high<\/jats:sup>T cells, and CD4<jats:sup>+<\/jats:sup>CTLA-4<jats:sup>+<\/jats:sup>T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>low<\/jats:sup>cells did not differ between groups.<jats:italic>Conclusion<\/jats:italic>. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis.<\/jats:p>","DOI":"10.1155\/2013\/710647","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T01:02:05Z","timestamp":1384822925000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Impaired Lymphocyte Profile in Schistosomiasis Patients with Periportal Fibrosis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Luciana Santos","family":"Cardoso","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, UFBA, 40171-115 Salvador-BA, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais (INCT-DT\/CNPq-MCT), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9ia de Souza Rocha","family":"Barreto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamille Souza","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Riccio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"},{"name":"Centro de Pesquisa Gon\u00e7alo Moniz, FIOCRUZ, 40296-710 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson da Paix\u00e3o de","family":"Souza","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais (INCT-DT\/CNPq-MCT), Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, 4050-420 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ilma","family":"Araujo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia (UFBA), 4110-160 Salvador-BA, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais (INCT-DT\/CNPq-MCT), Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, 4050-420 Salvador-BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/S1473-3099(06)70521-7"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0037-86822003000200003","volume":"36","year":"2003","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4049\/jimmunol.169.2.929","volume":"169","year":"2002","journal-title":"Journal of Immunology"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1111\/j.1365-3024.2009.01157.x"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1016\/S1383-5769(02)00031-4"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/0952-7915(95)80095-6"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1038\/nm1551"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1084\/jem.180.2.631"},{"issue":"6127","key":"9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/328267a0","volume":"328","year":"1987","journal-title":"Nature"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4049\/jimmunol.143.4.1123","volume":"143","year":"1989","journal-title":"Journal of Immunology"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1126\/science.1079490"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1111\/j.1600-0463.2004.apm1121002.x"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1146\/annurev.med.48.1.341"},{"issue":"1","key":"14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1172\/JCI2250","volume":"102","year":"1998","journal-title":"The Journal of Clinical Investigation"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1016\/S1286-4579(01)01450-2"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","volume":"167","year":"2001","journal-title":"Journal of Immunology"},{"key":"17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/0470871628.ch6","volume":"252","year":"2003","journal-title":"Novartis Foundation Symposium"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1016\/j.jri.2005.01.004"},{"issue":"5","key":"19","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2307\/3277532","volume":"56","year":"1970","journal-title":"Journal of Parasitology"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1155\/2012\/394981"},{"issue":"4","key":"21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4269\/ajtmh.1992.46.403","volume":"46","year":"1992","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"22","first-page":"143","volume":"87","year":"1992","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1128\/IAI.74.2.1215-1221.2006"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1016\/S1383-5769(03)00052-7"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/IAI.54.3.820-826.1986","volume":"54","year":"1986","journal-title":"Infection and Immunity"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1016\/j.actatropica.2008.04.010"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1111\/j.1365-3083.2009.02247.x"},{"key":"28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0074-02761998000700023","volume":"93","year":"1998","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.1016\/j.actatropica.2008.04.006"},{"issue":"2","key":"30","first-page":"281","volume":"80","year":"1993","journal-title":"Immunology"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.4049\/jimmunol.0900646"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1111\/j.1365-3024.2007.00947.x"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1371\/journal.pntd.0001383"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/710647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/710647.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/710647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T20:52:21Z","timestamp":1688676741000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2013\/710647\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":33,"alternative-id":["710647","710647"],"URL":"https:\/\/doi.org\/10.1155\/2013\/710647","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"type":"print","value":"1740-2522"},{"type":"electronic","value":"1740-2530"}],"subject":[],"published":{"date-parts":[[2013]]}}}