{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:13:46Z","timestamp":1770819226797,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PQ-311713-2012-2"],"award-info":[{"award-number":["PQ-311713-2012-2"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PQ-311713-2012-2"],"award-info":[{"award-number":["PQ-311713-2012-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PQ-311713-2012-2"],"award-info":[{"award-number":["PQ-311713-2012-2"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>.<jats:italic>Phrynops geoffroanus<\/jats:italic>is a small turtle that inhabits lakes, rivers, and streams throughout South America. The body fat of this animal is used as a folk medicine in Brazil for treating illnesses such as sore throats, ear aches, mumps, rheumatism, and arthritis. The present study evaluated the antimicrobial activity of oil extracted from<jats:italic>Phrynops geoffroanus<\/jats:italic>(OPG), determined its chemical composition, and discussed the implications of its use in traditional medicine. The OPG was obtained from the ventral region of this turtle using hexane as a solvent. The antimicrobial activity of OPG was tested against standard and multiresistance strains of bacteria and fungi and its composition was determined indirectly by analyzing the methyl esters of the component fatty acids. The OPG presented a clinically relevant antifungal activity against<jats:italic>Candida krusei<\/jats:italic>ATCC 6258 (MIC 128\u2009\u00b5g\/mL). When the OPG was associated with the antibacterial and antifungal drugs, was observed a synergistic effect when associated the OPG with the gentamicin against the strain<jats:italic>Pseudomonas aeruginosa<\/jats:italic>22. Our results indicated that OPG has clinically relevant antifungal activity against<jats:italic>C. krusei<\/jats:italic>, and demonstrated synergetic antibacterial activity in combination with commercial antibiotics against<jats:italic>Pseudomonas aeruginosa.<\/jats:italic><\/jats:p>","DOI":"10.1155\/2013\/715040","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T21:35:42Z","timestamp":1383687342000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Chemical Composition and Validation of the Ethnopharmacological Reported Antimicrobial Activity of the Body Fat of<i>Phrynops geoffroanus<\/i>Used in Traditional Medicine"],"prefix":"10.1155","volume":"2013","author":[{"given":"Di\u00f3genes de Queiroz","family":"Dias","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Eduardo Santos","family":"Cabral","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia de Recursos Naturais, BioMol-Lab, Departamento de Bioqu\u00edmica e Biologia Molecular, P.O. Box 6043, Universidade Federal do Cear\u00e1, Campus do Pici, 60455-970 Fortaleza, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Lima","family":"Sales","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Etnobiologia e Conserva\u00e7\u00e3o da Natureza, Universidade Federal Rural de Pernambuco\u2014UFRPE, 52171-900 Dois Irm\u00e3os, Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-4990","authenticated-orcid":true,"given":"Olga","family":"Paiva Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Antonio de Araujo","family":"Filho","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Galberto Martins","family":"da Costa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Regina","family":"Kerntopf","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f4mulo Romeu da N\u00f3brega","family":"Alves","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Universidade Estadual da Para\u00edba, 58429-500 Campina Grande, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walt\u00e9cio de 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