{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:40:35Z","timestamp":1788446435544,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa da Universidade Federal de Goi\u00e1s"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Synadenium umbellatum<\/jats:italic>\n                    Pax., popularly known in Brazil as \u201ccola-nota,\u201d \u201cavel\u00f3s,\u201d \u201ccancerola,\u201d and \u201cmilagrosa\u201d, is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract from\n                    <jats:italic>Synadenium umbellatum<\/jats:italic>\n                    Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol\/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail flick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail flick test. These results show that EES presented antinociceptive activity, probably involving the opioid system, anti-inflammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity. MF also presented anti-inflammatory activity in the croton oil-induced ear edema test. In conclusion, EES and MF have antinociceptive activity involving the opioid system and anti-inflammatory activity.\n                  <\/jats:p>","DOI":"10.1155\/2013\/715650","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T16:06:19Z","timestamp":1358784379000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract from\n                    <i>Synadenium umbellatum<\/i>\n                    Pax. (Euphorbiaceae) Leaves and Its Fractions"],"prefix":"10.1155","volume":"2013","author":[{"given":"Rodrigo","family":"Borges","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Avenida Universit\u00e1ria com 1a Avenida, Quadra 62, 2 Andar, Sala 36, 74605-220 Goi\u00e2nia, GO, Brazil"},{"name":"Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Avenida Nossa Senhora das Gra\u00e7as, 50 Xer\u00e9m, Duque de Caxias, 25250-020 Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vin\u00edcius Mariano","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Avenida Universit\u00e1ria com 1a Avenida, Quadra 62, 2 Andar, Sala 36, 74605-220 Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adryano Augustto Vallad\u00e3o","family":"de 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