{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:20:43Z","timestamp":1762521643924},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Vascular Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A were studied as risk factors in 235 Caucasian subjects: 85 patients with abdominal thrombosis (54 with portal vein thrombosis (PVT) and 31 with Budd-Chiari syndrome (BCS) without liver cirrhosis or hepatocellular carcinoma) and 150 blood bank donors. Seventy-five patients with PVT\/BCS showed associated disease or particular clinical status (46 PVT\/29 BCS): 37 myeloproliferative neoplasm (20 PVT\/17 BCS), 12 abdominal surgery (10 PVT\/2 BCS), 10 contraception or pregnancy (6 PVT\/4 BCS), 7 abdominal acute disease (6 PVT\/1 BCS), and 9 chronic disease (4 PVT\/5 BCS); ten patients did not present any association (8 PVT\/2 BCS). PAI-14G-4G, MTHFR677TT, and V Leiden 506Q were significantly frequent (OR 95% CI and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>test with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>value) in abdominal thrombosis; in these patients PAI-14G-4G and MTHFR677TT distributions deviated from that expected from a population in the Hardy-Weinberg equilibrium (PAI-1:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>13.8<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>; MTHFR677:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>7.1<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), whereas the equilibrium was respected in healthy controls. V Leiden Q506 and Prothrombin 20210A were in the Hardy-Weinberg equilibrium both in patients with abdominal thrombosis and healthy controls. Our study shows an important role of PAI-14G-4G and MTHFR677TT in abdominal thrombosis without liver cirrhosis or hepatocellular carcinoma.<\/jats:p>","DOI":"10.1155\/2013\/717480","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T21:59:12Z","timestamp":1387403952000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population"],"prefix":"10.1155","volume":"2013","author":[{"given":"Mario","family":"D\u2019Amico","sequence":"first","affiliation":[{"name":"Department of Biopathology and Medical and Forensic Biotechnologies and Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Sammarco","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Pasta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01215.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-008-0246-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.05.023"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085097"},{"key":"5","series-title":"World Health Organization Classification of Tumors","year":"2001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn359"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10192"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.09.005"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.02.014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.02.007"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1233-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00675-4"},{"issue":"7","key":"14","first-page":"2364","volume":"96","year":"2000","journal-title":"Blood"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1309\/F2U1-XBV4-RXYU-AYG0"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20591"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4518"},{"issue":"3","key":"18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7326\/0003-4819-151-3-200908040-00004","volume":"151","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.10.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.03.021"}],"container-title":["International Journal of Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2013\/717480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2013\/717480.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2013\/717480.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T04:31:15Z","timestamp":1498105875000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijvm\/2013\/717480\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"alternative-id":["717480","717480"],"URL":"https:\/\/doi.org\/10.1155\/2013\/717480","relation":{},"ISSN":["2090-2824","2090-2832"],"issn-type":[{"value":"2090-2824","type":"print"},{"value":"2090-2832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}