{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:27:19Z","timestamp":1761895639020,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T) is a hematological malignancy that combines features of both a myeloproliferative and myelodysplastic disorder. There have been recent reports of the successful treatment of anemia in 2 patients with RARS-T with lenalidomide. Here we report the successful treatment of massive splenomegaly in a patient with a long history of RARS-T resulting in complete resolution of splenomegaly, but with prolonged severe cytopenias. We also report the acquisition of the t(3;12)(q26;p13) translocation previously described in cases of myelodysplasia and the potential for transformation to myelofibrosis.<\/jats:p>","DOI":"10.1155\/2013\/718480","type":"journal-article","created":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T17:00:33Z","timestamp":1365354033000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis Complicated by Massive Splenomegaly Treated with Lenalidomide Resulting in Resolution of Splenomegaly but Severe and Prolonged Pancytopenia"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-7625","authenticated-orcid":true,"given":"Gordon","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Haematology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Culligan","sequence":"additional","affiliation":[{"name":"Department of Haematology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Department of Haematology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"journal-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"85","year":"2008","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404316"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013631"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-377994"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.232"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041668"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061292"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287417"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-263087"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03443.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.7356"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002028"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/718480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/718480.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/718480.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T13:31:30Z","timestamp":1469885490000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2013\/718480\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":12,"alternative-id":["718480","718480"],"URL":"https:\/\/doi.org\/10.1155\/2013\/718480","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2013]]}}}