{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:49:21Z","timestamp":1757310561335,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC30772023"],"award-info":[{"award-number":["NSFC30772023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSFC30772023"],"award-info":[{"award-number":["NSFC30772023"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Klebsiella pneumoniae<\/jats:italic>-associated pathology is largely mediated by neutrophilic inflammation. In this study, we administered<jats:italic>Klebsiella pneumoniae<\/jats:italic>to experimental guinea pig groups and the ELR-CXC chemokine antagonist<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>CXCL8<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mn>3<\/mml:mn><mml:mi>\u2013<\/mml:mi><mml:mn>72<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, ceftazidime, and dexamethasone to different groups, respectively. After 24\u2009h, we assessed the animal\u2019s pulmonary inflammatory levels, including gross histopathology, airway neutrophilia, lung myeloperoxidase levels, expressions of CXCL8 and TNF, and airway bacterial loads. Compared with ceftazidime and dexamethasone treatments, the administration of the ELR-CXC chemokine antagonist<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>CXCL8<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mn>3<\/mml:mn><mml:mi>\u2013<\/mml:mi><mml:mn>72<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>alone was more effective than other methods, although it did not markedly attenuate the bacterial load. These results suggest new methods for the treatment of<jats:italic>Klebsiella pneumoniae<\/jats:italic>pathology.<\/jats:p>","DOI":"10.1155\/2013\/720975","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T17:08:00Z","timestamp":1363626480000},"page":"1-6","source":"Crossref","is-referenced-by-count":12,"title":["CXCR1\/CXCR2 Antagonism Is Effective in Pulmonary Defense against<i>Klebsiella pneumoniae<\/i>Infection"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Immunology, Dalian Medical University, Dalian 116044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Karamay Central Hospital, Karamay 834000, 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