{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:34:35Z","timestamp":1778646875675,"version":"3.51.4"},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Plectranthus<\/jats:italic>is one of the most representative genera of Lamiaceae family. In this study, the essential oils from<jats:italic>Plectranthus amboinicus<\/jats:italic>,<jats:italic>Plectranthus ornatus<\/jats:italic>, and<jats:italic>Plectranthus barbatus<\/jats:italic>were investigated for their chemical composition and antimicrobial and modulatory activities. The major components found were carvacrol (54.4%\u2014<jats:italic>P. amboinicus<\/jats:italic>) and eugenol (22.9%\u2014<jats:italic>P. ornatus<\/jats:italic>e 25.1%\u2014<jats:italic>P. barbatus<\/jats:italic>).<jats:italic>In vitro<\/jats:italic>antimicrobial activity was conducted against<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic>Proteus vulgaris<\/jats:italic>,<jats:italic>Bacillus cereus<\/jats:italic>,<jats:italic>Pseudomonas aeruginosa<\/jats:italic>,<jats:italic>Staphylococcus aureus<\/jats:italic>, and<jats:italic>Staphylococcus aureus<\/jats:italic>(multiresistant) using microdilution method. The results of bioassay showed that all strains were sensitive to the oils, except<jats:italic>P. aeruginosa<\/jats:italic>that was resistant to<jats:italic>P. amboinicus<\/jats:italic>and<jats:italic>P. ornatus<\/jats:italic>. A synergistic effect of all essential oils combined with the aminoglycosides was demonstrated. These results show that<jats:italic>P. amboinicus<\/jats:italic>,<jats:italic>P. ornatus<\/jats:italic>, and<jats:italic>P. barbatus<\/jats:italic>inhibit the growth of pathogenic microorganism, and besides this they present antibiotic modifying activity, providing a new perspective against the problem of bacterial resistance to antibiotics.<\/jats:p>","DOI":"10.1155\/2013\/724161","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T22:29:00Z","timestamp":1365114540000},"page":"1-7","source":"Crossref","is-referenced-by-count":18,"title":["Study of the Interference between<i>Plectranthus<\/i>Species Essential Oils from Brazil and Aminoglycosides"],"prefix":"10.1155","volume":"2013","author":[{"given":"Fab\u00edola Fernandes","family":"Galv\u00e3o Rodrigues","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Rede Nordeste de Biotecnologia, Universidade Estadual do Cear\u00e1, Avenida Paranjana 1700, Campus do Itaperi, 60740-000 Fortaleza, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Galberto Martins","family":"Costa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Rede Nordeste de Biotecnologia, Universidade Estadual do Cear\u00e1, Avenida Paranjana 1700, Campus do Itaperi, 60740-000 Fortaleza, CE, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Departamento de Qu\u00edmica Biol\u00f3gica, Laborat\u00f3rio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Ant\u00f4nio Luiz 1161, Pimenta, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Fernandes Galvao","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Departamento de Qu\u00edmica Biol\u00f3gica, Laborat\u00f3rio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Ant\u00f4nio Luiz 1161, Pimenta, 63105-000 Crato, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Rolim","family":"Campos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioprospec\u00e7\u00e3o Molecular, Departamento de Qu\u00edmica Biol\u00f3gica, Laborat\u00f3rio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. 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