{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:25:23Z","timestamp":1791159923193,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\u201c<jats:italic>Frataxin fracas<\/jats:italic>\u201d were the words used when referring to the frataxin-encoding gene (<jats:italic>FXN<\/jats:italic>) burst in as a motive to disqualify an alternative candidate gene,<jats:italic>PIP5K1B<\/jats:italic>, as an actor in Friedreich's ataxia (FRDA) (Campuzano et al., 1996; Cossee et al., 1997; Carvajal et al., 1996). The instrumental role in the disease of large triplet expansions in the first intron of<jats:italic>FXN<\/jats:italic>has been thereafter fully confirmed, and this no longer suffers any dispute (Koeppen, 2011). On the other hand, a recent study suggests that the consequences of these large expansions in<jats:italic>FXN<\/jats:italic>are wider than previously thought and that the expression of surrounding genes, including<jats:italic>PIP5K1B<\/jats:italic>, could be concurrently modulated by these large expansions (Bayot et al., 2013). This recent observation raises a number of important and yet unanswered questions for scientists and clinicians working on FRDA; these questions are the substratum of this paper.<\/jats:p>","DOI":"10.1155\/2013\/725635","type":"journal-article","created":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T23:27:14Z","timestamp":1380583634000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Friedreich's Ataxia, Frataxin, PIP5K1B: Echo of a Distant Fracas"],"prefix":"10.1155","volume":"2013","author":[{"given":"Aur\u00e9lien","family":"Bayot","sequence":"first","affiliation":[{"name":"INSERM UMR 676, B\u00e2timent Ecran, H\u00f4pital Robert Debr\u00e9, 48 boulevard S\u00e9rurier, 75019 Paris, France"},{"name":"Universit\u00e9 Paris 7, Facult\u00e9 de M\u00e9decine Denis Diderot, Site Robert Debr\u00e9, 48 boulevard S\u00e9rurier, 75019 Paris, 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