{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:46:22Z","timestamp":1791859582133,"version":"4.3.4"},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"BioGreen 21 Program of the Rural Development Administration","award":["PJ009060"],"award-info":[{"award-number":["PJ009060"]}]},{"name":"BioGreen 21 Program of the Rural Development Administration","award":["IPET312060-5"],"award-info":[{"award-number":["IPET312060-5"]}]},{"name":"Bio-Industry Technology Development Program","award":["PJ009060"],"award-info":[{"award-number":["PJ009060"]}]},{"name":"Bio-Industry Technology Development Program","award":["IPET312060-5"],"award-info":[{"award-number":["IPET312060-5"]}]},{"name":"Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea","award":["PJ009060"],"award-info":[{"award-number":["PJ009060"]}]},{"name":"Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea","award":["IPET312060-5"],"award-info":[{"award-number":["IPET312060-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development. Antiepileptic drugs (AEDs) arouse concern for the risk of teratogenicity, but the data are limited. In this study, we evaluated the teratogenic potential of seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracetam (LVT), and topiramate (TPM)) in the zebrafish model. Zebrafish embryos were exposed to AEDs from initiation of gastrula (5.25 hours post-fertilization (hpf)) to termination of hatching (72\u2009hpf) which mimic the mammalian teratogenic experimental design. The lethality and teratogenic index (TI) of AEDs were determined and the TI values of each drug were compared with the US FDA human pregnancy categories. Zebrafish model was useful screening model for teratogenic potential of antiepilepsy drugs and was in concordance with<jats:italic>in vivo<\/jats:italic>mammalian data and human clinical data.<\/jats:p>","DOI":"10.1155\/2013\/726478","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T16:15:31Z","timestamp":1384445731000},"page":"1-6","source":"Crossref","is-referenced-by-count":41,"title":["Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model"],"prefix":"10.1155","volume":"2013","author":[{"given":"Sung Hak","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Animal Science & Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Won","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Animal Science & Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science & Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Animal Science & Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Animal Science & Biotechnology, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.2.195"},{"key":"2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0074-7742(08)00011-1","volume":"83","year":"2008","journal-title":"International Review of Neurobiology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.11.016"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20223"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.57"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20281"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2008.03.002"},{"key":"8","year":"2007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20214"},{"issue":"3","key":"10","first-page":"16","volume":"35","year":"2001","journal-title":"FDA Consumer Magazine"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","volume":"203","year":"1995","journal-title":"Developmental Dynamics"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.05.012"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.01.004"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2004.06.012"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20158"},{"issue":"9","key":"15","first-page":"876","volume":"17","year":"2012","journal-title":"Journal of Research in Medical Sciences"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(93)90111-H"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.05.004"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/726478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/726478.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/726478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T22:02:55Z","timestamp":1498082575000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/726478\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"alternative-id":["726478","726478"],"URL":"https:\/\/doi.org\/10.1155\/2013\/726478","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}