{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:16:06Z","timestamp":1791141366845,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen. However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.<\/jats:p>","DOI":"10.1155\/2013\/730131","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T21:08:24Z","timestamp":1366146504000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["Autoimmune Cytopenias in Chronic Lymphocytic Leukemia"],"prefix":"10.1155","volume":"2013","author":[{"given":"Giovanni","family":"D'Arena","sequence":"first","affiliation":[{"name":"Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Guariglia","sequence":"additional","affiliation":[{"name":"Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"La Rocca","sequence":"additional","affiliation":[{"name":"Laboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Trino","sequence":"additional","affiliation":[{"name":"Laboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Condelli","sequence":"additional","affiliation":[{"name":"Laboratory of Pre-clinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Martino","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences, University of Salerno, 84131 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-3207","authenticated-orcid":true,"given":"Vincenzo","family":"De Feo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences, University of Salerno, 84131 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[{"name":"Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"80","volume":"25","year":"1998","journal-title":"Seminars in Oncology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.01.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2008.1.450"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701344923"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-101303"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/039463200902200204","volume":"22","year":"2009","journal-title":"International Journal of Immunopathology and Pharmacology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286500"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2010.01.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08707.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036152"},{"issue":"12","key":"11","first-page":"828","volume":"8","year":"2006","journal-title":"Israel Medical Association Journal"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-111492"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","volume":"46","year":"1975","journal-title":"Blood"},{"key":"14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","volume":"48","year":"1981","journal-title":"Cancer"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093906"},{"key":"16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/CCO.0b013e328348c683","volume":"23","year":"2011","journal-title":"Current Opinion in Oncology"},{"key":"17","first-page":"3","volume":"18","year":"1973","journal-title":"Scandinavian Journal of Haematology"},{"issue":"4","key":"18","first-page":"296","volume":"33","year":"1988","journal-title":"Sangre"},{"issue":"9","key":"19","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1182\/blood.V95.9.2786.009k30_2786_2792","volume":"95","year":"2000","journal-title":"Blood"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10369"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.022079"},{"issue":"4","key":"22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V70.4.1105.1105","volume":"70","year":"1987","journal-title":"Blood"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/eji.1830210308","volume":"21","year":"1991","journal-title":"European Journal of Immunology"},{"issue":"7","key":"24","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1182\/blood.V87.7.2615.bloodjournal8772615","volume":"87","year":"1996","journal-title":"Blood"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-155663"},{"key":"26","first-page":"981","volume":"91","year":"2011","journal-title":"Annals of Hematology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101499"},{"issue":"7","key":"28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri844","volume":"2","year":"2002","journal-title":"Nature Reviews Immunology"},{"issue":"1","key":"29","first-page":"157","volume":"49","year":"1982","journal-title":"Clinical and Experimental Immunology"},{"issue":"2","key":"30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1182\/blood.V63.2.305.305","volume":"63","year":"1984","journal-title":"Blood"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/BF02914369"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0609.1996.tb00489.x","volume":"57","year":"1996","journal-title":"European Journal of Haematology"},{"issue":"1","key":"33","first-page":"27","volume":"25","year":"1998","journal-title":"Seminars in Oncology"},{"issue":"5-6","key":"34","first-page":"343","volume":"30","year":"1988","journal-title":"Nouvelle Revue Francaise d'Hematologie"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00194-1"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000029993"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2008.07.005"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1172\/JC135017"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.09.006"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-299321"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000059"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.08.010"},{"key":"43","volume":"4","year":"2012","journal-title":"Mediterranean Journal of Hematology and Infectious Diseases"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.728287"},{"issue":"1","key":"45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.169.1.255","volume":"169","year":"1989","journal-title":"Journal of Experimental Medicine"},{"issue":"10","key":"46","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1182\/blood.V81.10.2475.2475","volume":"81","year":"1993","journal-title":"Blood"},{"issue":"1","key":"47","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1200\/JCO.1999.17.1.399","volume":"17","year":"1999","journal-title":"Journal of Clinical Oncology"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10210"},{"issue":"1-2","key":"62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/10428199309054731","volume":"11","year":"1993","journal-title":"Leukemia and Lymphoma"},{"issue":"2","key":"63","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2141.1995.tb05300.x","volume":"91","year":"1995","journal-title":"British Journal of Haematology"},{"key":"65","volume":"104","year":"2004","journal-title":"Blood"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06513.x"},{"key":"69","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0140-6736(10)61381-5","volume":"376","year":"2010","journal-title":"Lancet"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3563"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90136-W"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02429.x"},{"issue":"1","key":"52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1182\/blood.V52.1.255.255","volume":"52","year":"1978","journal-title":"Blood"},{"issue":"5","key":"53","first-page":"489","volume":"9","year":"1981","journal-title":"Experimental Hematology"},{"issue":"5","key":"54","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1182\/blood.V59.5.990.990","volume":"59","year":"1982","journal-title":"Blood"},{"issue":"6","key":"55","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1172\/JCI110713","volume":"70","year":"1982","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood.V66.3.533.533","volume":"66","year":"1985","journal-title":"Blood"},{"issue":"1","key":"57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2141.1986.tb07495.x","volume":"63","year":"1986","journal-title":"British Journal of Haematology"},{"issue":"2","key":"58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajh.2830230211","volume":"23","year":"1986","journal-title":"American Journal of Hematology"},{"issue":"6","key":"59","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0002-9343(87)90943-0","volume":"83","year":"1987","journal-title":"American Journal of Medicine"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901283400405"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.09.001"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2319"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61125-8"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2395"},{"key":"70","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/bjh.12067","volume":"159","year":"2012","journal-title":"British Journal of Haematology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-259325"},{"key":"73","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1182\/blood-2011-12-309153","volume":"120","year":"2012","journal-title":"Blood"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.45"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.542598"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-001230"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01187.x"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01527.x"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404512"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402676"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.278"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/730131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/730131.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/730131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:32:45Z","timestamp":1715214765000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2013\/730131\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":81,"alternative-id":["730131","730131"],"URL":"https:\/\/doi.org\/10.1155\/2013\/730131","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"value":"1740-2522","type":"print"},{"value":"1740-2530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}