{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:57:59Z","timestamp":1771948679374,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    The aim of this study was to investigate the effects of age on hemispheric asymmetry in the auditory cortex after pure tone stimulation. Ten young and 8 older healthy volunteers took part in this study. Two\u2010dimensional multivoxel 1H\u2010magnetic resonance spectroscopy scans were performed before and after stimulation. The ratios of N\u2010acetylaspartate (NAA), glutamate\/glutamine (Glx), and\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010amino butyric acid (GABA) to creatine (Cr) were determined and compared between the two groups. The distribution of metabolites between the left and right auditory cortex was also determined. Before stimulation, left and right side NAA\/Cr and right side GABA\/Cr were significantly lower, whereas right side Glx\/Cr was significantly higher in the older group compared with the young group. After stimulation, left and right side NAA\/Cr and GABA\/Cr were significantly lower, whereas left side Glx\/Cr was significantly higher in the older group compared with the young group. There was obvious asymmetry in right side Glx\/Cr and left side GABA\/Cr after stimulation in young group, but not in older group. In summary, there is marked hemispheric asymmetry in auditory cortical metabolites following pure tone stimulation in young, but not older adults. This reduced asymmetry in older adults may at least in part underlie the speech perception difficulties\/presbycusis experienced by aging adults.\n                  <\/jats:p>","DOI":"10.1155\/2013\/735290","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T05:51:28Z","timestamp":1382593888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Age\u2010Associated Reduction of Asymmetry in Human Central Auditory Function: A 1H\u2010Magnetic Resonance Spectroscopy Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Xianming","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1009"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04315.x"},{"key":"e_1_2_5_3_2","first-page":"247","article-title":"Anatomic asymmetries of the posterior superior temporal lobes: a postmortem study","volume":"12","author":"Anderson B.","year":"1999","journal-title":"Neuropsychiatry, Neuropsychology and Behavioral Neurology"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.5.512"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5486.1946"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0165-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.5.661"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0021878299006901"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.12.2400"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.765"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942011000100005"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-0042-1745594","article-title":"Aging affects hemispheric asymmetry on a competing speech task","volume":"12","author":"Greenwald R. 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