{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:17Z","timestamp":1760122337514,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100009210","name":"Taiwan Food and Drug Administration","doi-asserted-by":"crossref","award":["DOH101-FDA-61401","DOH102-FDA-61102"],"award-info":[{"award-number":["DOH101-FDA-61401","DOH102-FDA-61102"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009210","name":"Taiwan Food and Drug Administration","doi-asserted-by":"crossref","award":["DOH101-FDA-61401","DOH102-FDA-61102"],"award-info":[{"award-number":["DOH101-FDA-61401","DOH102-FDA-61102"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>This pilot study simultaneously evaluated the effects of various factors, including genetic variations of<jats:italic>CYP2B6<\/jats:italic>,<jats:italic>CYP2C19<\/jats:italic>, and<jats:italic>ABCB1<\/jats:italic>, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose,<jats:italic>CYP2B6<\/jats:italic>785G allele, and<jats:italic>ABCB1<\/jats:italic>2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.<\/jats:p>","DOI":"10.1155\/2013\/741403","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T16:03:27Z","timestamp":1387209807000},"page":"1-11","source":"Crossref","is-referenced-by-count":13,"title":["Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan"],"prefix":"10.1155","volume":"2013","author":[{"given":"Hsin-Ya","family":"Lee","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih-Heng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"},{"name":"Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh-Ling","family":"Sheu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Pei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Addiction and Forensic Psychiatry, Jianan Mental Hospital, No. 80, Lane 870, Jhong-Shan Road, Rende District, Tainan City 71742, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chiao","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Taipei Medical University, No. 250 Wu-Shin Street, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Chun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"},{"name":"Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing-Yaw","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray-H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Fooyin University, No. 151 Ching-Hsueh Road, Kaohsiung City 831, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"journal-title":"Cochrane Database of Systematic Reviews","issue":"3","year":"2003","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2007.08.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-007-9178-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(01)00171-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.116793"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.05.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315479"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011023431802"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2011.10.022"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.12.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2006.03.012"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(99)00084-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00527-6"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90004-H"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1747-597X-7-11"},{"issue":"3","key":"16","first-page":"10","volume":"21","year":"2002","journal-title":"American clinical laboratory"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200202000-00005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.276"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0293-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.09.012"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10303"},{"issue":"2","key":"22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF03256276","volume":"12","year":"2008","journal-title":"Molecular Diagnosis and Therapy"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00274.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.09.011"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00628.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100120"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318192eb00"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00426-S"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.03.030"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1718-1"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.96"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318222b5dd"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.011"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019527"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2011.10.006"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60291-8"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150180627"},{"issue":"4","key":"38","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1369-1600.2011.00349.x","volume":"18","year":"2013","journal-title":"Addiction Biology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.09.012"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1086\/427441"},{"issue":"2","key":"41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1874473710801020177","volume":"1","year":"2008","journal-title":"Current drug abuse reviews"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.09.004"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(01)00198-2"},{"issue":"1\u20133","key":"44","first-page":"91","volume":"123","year":"2011","journal-title":"Drug and Alcohol Dependence"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1080\/09595230601036994"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283523d27"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3109\/10550490903205652"},{"issue":"2","key":"48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1300\/J069v19n02_03","volume":"19","year":"2000","journal-title":"Journal of Addictive Diseases"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1080\/10550880802122620"},{"issue":"6","key":"50","first-page":"6","volume":"8","year":"2011","journal-title":"Substance Abuse Treatment, Prevention, and Policy"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.01.004"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200107000-00004"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/741403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/741403.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/741403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:20:02Z","timestamp":1498090802000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/741403\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":52,"alternative-id":["741403","741403"],"URL":"https:\/\/doi.org\/10.1155\/2013\/741403","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2013]]}}}