{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:27:04Z","timestamp":1783945624608,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010656","name":"Canadian Celiac Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010656","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>BACKGROUND: Celiac disease can present with mild or nongastrointestinal symptoms, and may escape timely recognition. The treatment of celiac disease involves a gluten-free diet, which is complex and challenging.<\/jats:p><jats:p>OBJECTIVE: To evaluate clinical features and symptom recovery on a gluten-free diet in a Canadian adult celiac population.<\/jats:p><jats:p>METHODS: All adult members (n=10,693) of the two national celiac support organizations, the Canadian Celiac Association and<jats:italic>Fondation qu\u00e9b\u00e9coise de la maladie coeliaque,<\/jats:italic>were surveyed using a questionnaire.<\/jats:p><jats:p>RESULTS: A total of 5912 individuals (\u226518 years of age) with biopsy-confirmed celiac disease and\/or dermatitis herpetiformis completed the survey. The female to male ratio was 3:1, and mean (\u00b1 SD) age at diagnosis was 45.2\u00b116.4 years. Mean time to diagnosis after onset of symptoms was 12.0\u00b114.4 years. Abdominal pain and bloating (84.9%), extreme weakness\/tiredness (74.2%), diarrhea (71.7%) and anemia (67.8%) were the most commonly reported symptoms at the time of diagnosis. Many respondents continued to experience symptoms after being on a gluten-free diet for &gt;5 years. Sex differences were reported in clinical features before diagnosis, recovery after being on gluten-free diet and perceived quality of life, with women experiencing more difficulties than men.<\/jats:p><jats:p>CONCLUSIONS: Delays in diagnosis of celiac disease in Canada remain unacceptably long despite wider availability of serological screening tests. Many patients report continuing symptoms despite adhering to a gluten-free diet for &gt;5 years, with women experiencing more symptoms and a lower recovery rate than men. Awareness of celiac disease needs improvement, and follow-up with a physician and a dietitian is essential for all patients with celiac disease.<\/jats:p>","DOI":"10.1155\/2013\/741740","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:03:40Z","timestamp":1458029020000},"page":"449-453","source":"Crossref","is-referenced-by-count":56,"title":["Clinical Features and Symptom Recovery on a Gluten-Free Diet in Canadian Adults with Celiac Disease"],"prefix":"10.1155","volume":"27","author":[{"given":"Olga","family":"Pulido","sequence":"first","affiliation":[{"name":"Food Directorate, Health Canada, Canada"},{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Zarkadas","sequence":"additional","affiliation":[{"name":"Canadian Celiac Association, Professional Advisory Board, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Dubois","sequence":"additional","affiliation":[{"name":"Food Directorate, Health Canada, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"Canadian Celiac Association, Mississauga, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cantin","sequence":"additional","affiliation":[{"name":"Food Directorate, Health Canada, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"La Vieille","sequence":"additional","affiliation":[{"name":"Food Directorate, Health Canada, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Godefroy","sequence":"additional","affiliation":[{"name":"Food Directorate, Health Canada, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Rashid","sequence":"additional","affiliation":[{"name":"Canadian Celiac Association, Professional Advisory Board, Canada"},{"name":"Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2013\/741740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2013\/741740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T16:04:31Z","timestamp":1589645071000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2013\/741740\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013]]}},"alternative-id":["741740"],"URL":"https:\/\/doi.org\/10.1155\/2013\/741740","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}