{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:59:42Z","timestamp":1792159182541,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Graduate Scholarship"},{"DOI":"10.13039\/501100000145","name":"Alberta Innovates Health Solutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH\n                    <jats:sub>2<\/jats:sub>\n                    : PAR1-TF) on ethanol-DNBS-induced inflammation.\n                    <jats:italic>Results<\/jats:italic>\n                    . Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH\n                    <jats:sub>2<\/jats:sub>\n                    . Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor.\n                  <\/jats:p>","DOI":"10.1155\/2013\/748395","type":"journal-article","created":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T16:32:17Z","timestamp":1388334737000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis"],"prefix":"10.1155","volume":"2013","author":[{"given":"M. Mark","family":"Stanton","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4"},{"name":"Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4"},{"name":"Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4"},{"name":"Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4"},{"name":"Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 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