{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:44:35Z","timestamp":1789803875680,"version":"4.0.1"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>This prospective cohort study was conducted to determine the frequency of infections caused by extended-spectrum beta-lactamase- (ESBL-) producing organisms, various bacteria producing ESBL, antibiotic susceptibility of these organisms, and the risk factors associated with these infections in a neonatal intensive care unit in a tertiary care hospital in North India. Of the 150 neonates enrolled in the study, 47 culture-positive neonates were included in the study cohort and were divided into two groups: ESBL-positive (8 neonates) and ESBL-negative (39 neonates) cohorts. Various organisms were isolated from 72 culture samples in these 47 neonates. Of these, 10 culture samples grew ESBL-positive organisms and 62 samples grew ESBL-negative organisms. The frequency of ESBL-producing organisms was found to be 5.3%. ESBL infection incidence densities were found to be 3.4 per 1000 patient-days.<jats:italic>Klebsiella<\/jats:italic>(60%) was the most common organism producing ESBL followed by<jats:italic>Escherichia coli<\/jats:italic>(30%) and<jats:italic>Pseudomonas<\/jats:italic>(10%). Eighty percent of the ESBL-producing organisms were sensitive to piperacillin-tazobactam. Risk factors found significant by univariate analysis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) were preterm, low birthweight, perinatal asphyxia, respiratory distress syndrome, anaemia, metabolic acidosis, prolonged mechanical ventilation (&gt;7 days), length of hospitalization, length of level 3 stay, prior antibiotic use, central venous catheter duration, peripherally inserted central venous catheter duration, and total parenteral nutrition duration. Factors that retained significance in the logistic regression model were duration of hospital stay (adjusted OR: 0.958, CI: 0.920\u20130.997, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>value = 0.037) and gestational age (adjusted OR: 1.39, CI: 1.037\u20131.865, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>value = 0.028). There was no significant difference in the mortality between the two groups.<\/jats:p>","DOI":"10.1155\/2013\/756209","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T01:33:53Z","timestamp":1380072833000},"page":"1-8","source":"Crossref","is-referenced-by-count":24,"title":["Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Nandini","family":"Vijayakanthi","sequence":"first","affiliation":[{"name":"Department of Paediatrics & Neonatology, PGIMER & Associated Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Bahl","sequence":"additional","affiliation":[{"name":"Department of Paediatrics & Neonatology, PGIMER & Associated Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmaljit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Microbilogy, PGIMER & Associated Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Maria","sequence":"additional","affiliation":[{"name":"Department of Paediatrics & Neonatology, PGIMER & Associated Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nand Kishore","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Paediatrics & Neonatology, PGIMER & Associated Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, 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