{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:30Z","timestamp":1787017710147,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, Moscow, Russia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2013]]},"abstract":"\n The aim of the present study was to evaluate the potential antidiabetic effects of two-component drug Subetta and its components (release-active dilutions of antibodies to\n \u03b2<\/jats:italic>\n -subunit insulin receptor (RAD of Abs to\n \u03b2<\/jats:italic>\n -InsR) and to endothelial nitric oxide synthase (RAD of Abs to eNOS)) in Goto-Kakizaki (Paris colony) (GK\/Par) diabetic rats. Subetta was administered orally for 28 days once daily (5\u2009mL\/kg) and compared to its two components (2.5\u2009mL\/kg), Rosiglitazone (5\u2009mg\/kg), and vehicle (5\u2009mL water\/kg). At day 28, fasting plasma glucose levels were significantly decreased only in Subetta and Rosiglitazone groups as compared to vehicle (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.01<\/mml:mn>\n <\/mml:math>\n ):\n \n 147<\/mml:mn>\n \u00b1<\/mml:mo>\n 4<\/mml:mn>\n <\/mml:math>\n \u2009mg\/dL and\n \n 145<\/mml:mn>\n \u00b1<\/mml:mo>\n 4<\/mml:mn>\n <\/mml:math>\n \u2009mg\/dL and\n \n 165<\/mml:mn>\n \u00b1<\/mml:mo>\n 4<\/mml:mn>\n <\/mml:math>\n \u2009mg\/dL, respectively. The data of glucose tolerance test showed that Subetta and RAD of Abs to\n \u03b2<\/jats:italic>\n -InsR (similar to Rosiglitazone) prevented significantly (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.01<\/mml:mn>\n <\/mml:math>\n ) the age-related spontaneous deterioration of glucose tolerance as seen in the control group. Subetta and RAD of Abs to\n \u03b2<\/jats:italic>\n -InsR did not significantly modify the glucose-induced insulin secretion. Chronic administration of Subetta and RAD of Abs to\n \u03b2<\/jats:italic>\n -InsR improves glucose control, to an extent similar to that of Rosiglitazone. We hypothesize that Subetta and RAD of Abs to\n \u03b2<\/jats:italic>\n -InsR mostly act via an insulin-sensitizing effect upon target tissues.\n <\/jats:p>","DOI":"10.1155\/2013\/763125","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T17:35:47Z","timestamp":1368034547000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone"],"prefix":"10.1155","volume":"2013","author":[{"given":"Danielle","family":"Bailb\u00e9","sequence":"first","affiliation":[{"name":"Laboratoire B2PE (Biologie et Pathologie du Pancr\u00e9as Endocrine), Unit\u00e9 BFA (Biologie Fonctionnelle et Adaptive), Equipe 1, Universit\u00e9 Paris-Diderot et CNRS EAC 4413, B\u00e2timent Buffon, 5\u00e9me \u00e9tage, Pi\u00e9ce 552A, 4, rue Lagroua Weill Hall\u00e9, Case 7126, 75205 Paris Cedex 13, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwann","family":"Philippe","sequence":"additional","affiliation":[{"name":"Laboratoire B2PE (Biologie et Pathologie du Pancr\u00e9as Endocrine), Unit\u00e9 BFA (Biologie Fonctionnelle et Adaptive), Equipe 1, Universit\u00e9 Paris-Diderot et CNRS EAC 4413, B\u00e2timent Buffon, 5\u00e9me \u00e9tage, Pi\u00e9ce 552A, 4, rue Lagroua Weill Hall\u00e9, Case 7126, 75205 Paris Cedex 13, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Gorbunov","sequence":"additional","affiliation":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, 3rd Samotyochny Per., 9, Moscow 127473, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Tarasov","sequence":"additional","affiliation":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, 3rd Samotyochny Per., 9, Moscow 127473, 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