{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T13:26:52Z","timestamp":1778419612378,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Kuopio University Hospital"},{"name":"Juho Vainio Foundation"},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008368","name":"Finnish Anti-Tuberculosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008368","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cholesterol"],"published-print":{"date-parts":[[2013,5,16]]},"abstract":"<jats:p>To evaluate whether parameters of obstructive sleep apnoea (OSA) associate with cholesterol metabolism before and after weight reduction, 42 middle-aged overweight subjects with mild OSA were randomised to intensive lifestyle intervention (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>23<\/mml:mn><\/mml:mrow><\/mml:math>) or to control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>18<\/mml:mn><\/mml:mrow><\/mml:math>) with routine lifestyle counselling only. Cholesterol metabolism was evaluated with serum noncholesterol sterol ratios to cholesterol, surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholestenol, desmosterol, and lathosterol) at baseline and after 1-year intervention. At baseline, arterial oxygen saturation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>Sa<\/mml:mtext><\/mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>) was associated with serum campesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) and inversely with desmosterol ratios (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) independently of gender, BMI, and homeostasis model assessment index of insulin resistance (HOMA-IR). Apnoea-hypopnoea index (AHI) was not associated with cholesterol metabolism. Weight reduction significantly increased<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>Sa<\/mml:mtext><\/mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and serum cholestanol and decreased AHI and serum cholestenol ratios. In the groups combined, the changes in AHI were inversely associated with changes of cholestanol and positively with cholestenol ratios independent of gender and the changes of BMI and HOMA-IR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). In conclusion, mild OSA seemed to be associated with cholesterol metabolism independent of BMI and HOMA-IR. Weight reduction increased the markers of cholesterol absorption and decreased those of cholesterol synthesis in the overweight subjects with mild OSA.<\/jats:p>","DOI":"10.1155\/2013\/769457","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T21:04:54Z","timestamp":1368738294000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Cholesterol Metabolism and Weight Reduction in Subjects with Mild Obstructive Sleep Apnoea: A Randomised, Controlled Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maarit","family":"Hallikainen","sequence":"first","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, P.O. 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