{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:04:56Z","timestamp":1761293096046},"reference-count":9,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Cushing\u2019s syndrome is characterized by any cause of excess cortisol in the blood and produces many physiologic consequences. Left untreated, Cushing\u2019s is associated with significant morbidity and mortality. Seventy percent of endogenous cases of Cushing\u2019s syndrome are secondary to a pituitary tumor; because of this, the primary mode of management is surgical resection of the tumor. Should hypercortisolism persist following surgical resection, further treatment options are limited. Metyrapone is an orphan medication that is often used in the diagnosis of the disease and occasionally for short-term treatment prior to surgery. Long-term treatment with metyrapone is usually discouraged due to the contradictory increase in ACTH production, acne, hirsutism, hyperkalemia, edema, and other mineralocorticoid effects. We present a patient with refractory Cushing\u2019s syndrome successfully treated for nearly 6 years with metyrapone with minimal adverse effects. This orphan medication may be a viable long-term treatment option for this difficult disease.<\/jats:p>","DOI":"10.1155\/2013\/782068","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T16:03:48Z","timestamp":1386864228000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Metyrapone for Long-Term Medical Management of Cushing\u2019s Syndrome"],"prefix":"10.1155","volume":"2013","author":[{"given":"Andrea N.","family":"Traina","sequence":"first","affiliation":[{"name":"AstraZeneca LP, 1800 Concord Pike, Wilmington, DE 19803, USA"},{"name":"St. John Fisher College\u2019s Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY 14618, USA"},{"name":"Endocrine-Diabetes Care and Resource Center, Rochester General Health System, 224 Alexander Park, Suite 200, Rochester, NY 4607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Farr","sequence":"additional","affiliation":[{"name":"St. John Fisher College\u2019s Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY 14618, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Malik","sequence":"additional","affiliation":[{"name":"Endocrine-Diabetes Care and Resource Center, Rochester General Health System, 224 Alexander Park, Suite 200, Rochester, NY 4607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Bingham","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA"},{"name":"Unity Diabetes Center, 2655 Ridgeway Avenue, Suite 220, Rochester, NY 14626, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68699-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2112"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2734"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.7.2647"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02380.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/138955707780619653"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1159\/000314292"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105743"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1210\/jc.2011-3350","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/782068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/782068.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2013\/782068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:09:59Z","timestamp":1498090199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crie\/2013\/782068\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":9,"alternative-id":["782068","782068"],"URL":"https:\/\/doi.org\/10.1155\/2013\/782068","relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}