{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:43:15Z","timestamp":1780587795549,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Polyamines are substances involved in many aspects of cell growth, division, and differentiation. Because of the metabolic differences between host cells and parasite cells, polyamine metabolism has been considered as a potential target for the chemotherapy of parasitic diseases. The aim of this work was to evaluate the schistosomicidal activity of different<jats:italic>N<\/jats:italic>-alkylated diamines (<jats:bold>3a<\/jats:bold>\u2013<jats:bold>3h<\/jats:bold>), amino alcohols (<jats:bold>4a<\/jats:bold>\u2013<jats:bold>4d<\/jats:bold>), and glycosylated amino alcohols (<jats:bold>10a<\/jats:bold>\u2013<jats:bold>10d<\/jats:bold>). Compounds were prepared by synthetic methods and submitted to<jats:italic>in vitro<\/jats:italic>evaluation against adult worms of<jats:italic>Schistosoma mansoni<\/jats:italic>. At 100\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>M,<jats:bold>3b<\/jats:bold>,<jats:bold>3e<\/jats:bold>, and<jats:bold>3h<\/jats:bold>as well as<jats:bold>4a<\/jats:bold>,<jats:bold>4b<\/jats:bold>,<jats:bold>4d<\/jats:bold>,<jats:bold>10a<\/jats:bold>,<jats:bold>10b<\/jats:bold>, and<jats:bold>10d<\/jats:bold>resulted in 100% mortality of adult schistosomes. Compound<jats:bold>3d<\/jats:bold>(12.5 to 100\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>M) caused the death of 100% of both male and female adult schistosomes, while<jats:bold>3f<\/jats:bold>(12.5 to 100\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>M) resulted in 100% mortality of only male adult worms, whereas no mortality in female worms was observed. Compounds<jats:bold>3d<\/jats:bold>and<jats:bold>3f<\/jats:bold>were also able to reduce viability and decrease production of developed eggs in comparison with the negative control group. Diamines<jats:bold>3d<\/jats:bold>and<jats:bold>3f<\/jats:bold>may represent useful lead compounds for further optimization in order to develop new schistosomicidal agents.<\/jats:p>","DOI":"10.1155\/2013\/783490","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T21:31:40Z","timestamp":1377034300000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against<i>Schistosoma mansoni<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"F\u00e1bio de Souza","family":"Fernandes","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso O.","family":"Rezende J\u00fanior","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayrine Silva","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia Souza","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A. M.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro V.","family":"De Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato G.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Universidade de S\u00e3o Paulo, 14049-900 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Universidade de S\u00e3o Paulo, 14049-900 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar A.","family":"Da Silva Filho","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Faculdade de Farm\u00e1cia, Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R. 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