{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:27:32Z","timestamp":1740166052391,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutics"],"published-print":{"date-parts":[[2013,11,26]]},"abstract":"<jats:p>The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complexation reactions between risperidone (RSP) as <jats:italic>n<\/jats:italic>-electron donor and <jats:italic>p<\/jats:italic>-chloranilic acid (<jats:italic>p<\/jats:italic>-CA) in method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in method B as <jats:italic>\u03c0<\/jats:italic>-acceptors. In method A, RSP reacts with <jats:italic>p<\/jats:italic>-CA in methanol to produce a bright pink-colored chromogen measured at 530\u2009nm whereas, in method B, RSP reacts with DDQ in dichloromethane to form orange-colored complex with a maximum absorption at 460\u2009nm. Beer's law was obeyed in the concentration range of 0\u201325 and 0\u201350\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL with molar absorptivity of  and  L\/moL\/cm for RSP in methods A and B, respectively. The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures. The proposed methods have been successfully applied to the determination of RSP in pharmaceutical formulations. Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation  %).<\/jats:p>","DOI":"10.1155\/2013\/792186","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T21:09:12Z","timestamp":1353964152000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms"],"prefix":"10.1155","volume":"2013","author":[{"given":"Hemavathi Nagaraju","family":"Deepakumari","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-3599","authenticated-orcid":true,"given":"Hosakere Doddarevanna","family":"Revanasiddappa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume":"1","year":"2005","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.06.013"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-007-0506-1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00323-6"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-010-1580-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.02.007"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2006.10.049"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2537"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.04.041"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00302-2"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2004.07.014"},{"key":"12","first-page":"122","volume":"1","year":"2010","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.56.1092"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1021\/ac951084a","volume":"68","year":"1996","journal-title":"Analytical Chemistry"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1021\/ja01847a025","volume":"63","year":"1941","journal-title":"Journal of the American Chemical Society"},{"issue":"4","key":"16","first-page":"237","volume":"40","year":"1985","journal-title":"Journal de Pharmacie de Belgique"}],"container-title":["Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/792186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/792186.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/792186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T15:07:20Z","timestamp":1607612840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jphar\/2013\/792186\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":16,"alternative-id":["792186","792186"],"URL":"https:\/\/doi.org\/10.1155\/2013\/792186","relation":{},"ISSN":["2090-9918","2090-7818"],"issn-type":[{"type":"print","value":"2090-9918"},{"type":"electronic","value":"2090-7818"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}