{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:41:06Z","timestamp":1753886466307,"version":"3.41.2"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Increased viscosity may increase the risk of thrombosis or thromboembolic events. Recombinant human erythropoietin (rHuEPO) is the key stone treatment in anemic ESRD patients with the thrombotic limiting side effect. We evaluated the influence of clinical and laboratory findings on plasma viscosity in MHD patients in the present study. <jats:italic>Method<\/jats:italic>. After applying exclusion criteria 84 eligible MHD patients were included (30 female, age: 54.7 \u00b1 13.7 years). <jats:italic>Results<\/jats:italic>. Patients with high viscosity had longer MHD history, calcium \u00d7 phosphorus product, and higher rHuEPO requirement (356.4 versus 204.2\u2009U\/kg\/week, <jats:italic>P<\/jats:italic>: 0.006). rHuEPO hyporesponsiveness was also more common in hyperviscosity group. According to HD duration, no rHuEPO group had the longest and the low rHuEPO dosage group had the shortest duration. Despite similar Hb levels, 68% of patients in high rHuEPO dosage group; and 38.7% of patients in low rHuEPO dosage group had higher plasma viscosity (<jats:italic>P<\/jats:italic>: 0.001). Patients with hyperviscosity had higher rHuEPO\/Hb levels (<jats:italic>P<\/jats:italic>: 0.021). Binary logistic regression analyses revealed that rHuEPO hyporesponsiveness was the major determinant of hyperviscosity. <jats:italic>Conclusion<\/jats:italic>. We suggest that the hyperviscous state of the hemodialysis patients may arise from the inflammatory situation of long term HD, the calcium\u2010phosphorus mineral abnormalities, rHuEPO hyporesponsiveness, and related high dosage requirements.<\/jats:p>","DOI":"10.1155\/2013\/792698","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T03:27:21Z","timestamp":1380598041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["rHuEPO Hyporesponsiveness and Related High Dosages Are Associated with Hyperviscosity in Maintenance Hemodialysis Patients"],"prefix":"10.1155","volume":"2013","author":[{"given":"Mehtap","family":"Erkmen Uyar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-5827","authenticated-orcid":false,"given":"Selami Kocak","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Saglam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Tutal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Bay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Ilhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-8388","authenticated-orcid":false,"given":"Siren","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"295","article-title":"Blood viscosity and its relationship with plasma fibrinogen and cholesterol levels in young obese patients","volume":"6","author":"Yonem A.","year":"1999","journal-title":"Turkish Medical Journal"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-1992-12409"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.5.768"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.06.011"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.11.2355"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.336"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199601000-00008"},{"key":"e_1_2_7_8_2","first-page":"200","article-title":"Effects of human recombinant erythropoietin on inflammatory status in peritoneal dialysis patients","volume":"18","author":"Aguilera A.","year":"2002","journal-title":"Advances in Peritoneal Dialysis"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648479"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.30.2.S97"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.3.679"},{"key":"e_1_2_7_12_2","article-title":"Erythropoietin, thrombomodulin, factor von Willebrand and hemodialysis","volume":"8","author":"Stasko J.","year":"1995","journal-title":"Revista Iberoamericana de Trombosis y Hemostasia"},{"key":"e_1_2_7_13_2","first-page":"277","article-title":"The effects of recombinant human erythropoietin on hemostasis and fibrinolysis in hemodialysis patients","volume":"38","author":"Wirtz J. 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