{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:34:55Z","timestamp":1771846495955,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 100-2314-B-182-046"],"award-info":[{"award-number":["NSC 100-2314-B-182-046"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["370791"],"award-info":[{"award-number":["370791"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["NSC 100-2314-B-182-046"],"award-info":[{"award-number":["NSC 100-2314-B-182-046"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["370791"],"award-info":[{"award-number":["370791"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Study Objectives.<\/jats:italic>The aim of this study is to investigate the correlation between serum high-sensitivity C-reactive protein (hs-CRP) and other clinical tools including high-resolution computed tomography (HRCT) in patients with stable non-CF bronchiectasis.<jats:italic>Design.<\/jats:italic>A within-subject correlational study of a group of patients with stable non-CF bronchiectasis, who were recruited from our outpatient clinic, was done over a two-year period.<jats:italic>Measurements.<\/jats:italic>Sixty-nine stable non-CF bronchiectasis patients were evaluated in terms of hs-CRP, 6-minute walk test, pulmonary function tests, and HRCT.<jats:italic>Results.<\/jats:italic>Circulating hs-CRP levels were significantly correlated with HRCT scores (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>69<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.473<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>001<\/mml:mn><\/mml:math>) and resting oxygenation saturation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0.269<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.025<\/mml:mn><\/mml:math>). HRCT severity scores significantly increased in patients with hs-CRP level of 4.26\u2009mg\/L or higher (mean \u00b1 SD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>28.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>13.1<\/mml:mn><\/mml:math>) compared to those with hs-CRP level less than 4.26\u2009mg\/L (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn>31.7<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9.8<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>). Oxygenation saturation at rest was lower in those with hs-CRP level of 4.26\u2009mg\/L or higher (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mn>93.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.4<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:math>) compared to those with hs-CRP level less than 4.26\u2009mg\/L (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mn>96.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.6<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>).<jats:italic>Conclusion.<\/jats:italic>There was a good correlation between serum hs-CRP and HRCT scores in the patients with stable non-CF bronchiectasis.<\/jats:p>","DOI":"10.1155\/2013\/795140","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T16:01:12Z","timestamp":1386432072000},"page":"1-8","source":"Crossref","is-referenced-by-count":20,"title":["The Role of the High-Sensitivity C-Reactive Protein in Patients with Stable Non-Cystic Fibrosis Bronchiectasis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Meng-Heng","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine, Chang Gung Medical Foundation, Department of Chest Medicine, Chang Gung University, College of Medicine, Taoyuan 33342, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Fu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Chang Gung Medical Foundation, Department of Chest Medicine, Chang Gung University, College of Medicine, Taoyuan 33342, 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