{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:11:41Z","timestamp":1759385501599},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies. We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes. This cross-sectional study with prospective followup for almost 4 years was performed on 94 prevalent hemodialysis patients. Obestatin, leptin, proinflammatory cytokines (tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>[TNF-<jats:italic>\u03b1<\/jats:italic>], interleukin-6, and various nutritional markers were measured. Patients with low obestatin levels, defined as a level less than median, had a worse all-cause mortality and cardiovascular mortality. The crude all-cause (HR 2.23, 95% CI 1.17 to 4.24) and cardiovascular mortality hazard ratios (HR 4.03, 95% CI 1.27 to 12.76) in these patients continued to be significant after adjustment for various confounders for all-cause mortality. Across the four obestatin-TNF-<jats:italic>\u03b1<\/jats:italic>categories, the group with low obestatin and high TNF-<jats:italic>\u03b1<\/jats:italic>(above median level) exhibited a worse outcome in both all-cause mortality and cardiovascular mortality. Clinical characteristics of patients in low obestatin high TNF-<jats:italic>\u03b1<\/jats:italic>group did not differ from other obestatin-TNF-<jats:italic>\u03b1<\/jats:italic>categorized groups. In summary, low serum obestatin concentration is an independent predictor of mortality in prevalent hemodialysis patients. Novel interactions were observed between obestatin and TNF-<jats:italic>\u03b1<\/jats:italic>, which were associated with mortality risk, especially those due to cardiovascular causes.<\/jats:p>","DOI":"10.1155\/2013\/796586","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T21:05:31Z","timestamp":1379019931000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ilia","family":"Beberashvili","sequence":"first","affiliation":[{"name":"Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, 70300 Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Sinuani","sequence":"additional","affiliation":[{"name":"Pathology Department, Assaf Harofeh Medical Center, Affiliated to 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