{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:29:29Z","timestamp":1773768569660,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"Purpose<\/jats:italic>. To report the onset of severe macular edema in adolescent female patients affected by juvenile idiopathic arthritis (JIA).Methods<\/jats:italic>. Four female patients affected by JIA-related chronic anterior uveitis (CAU), complicated by severe macular edema, were retrospectively analyzed. Macular area was evaluated by fluorescein angiography and optical coherence tomography (OCT).Results<\/jats:italic>. CAU was bilateral in three patients. Mean age of uveitis and arthritis onset was, respectively,4.5<\/mml:mn>\u00b1<\/mml:mo>1.7<\/mml:mn><\/mml:math>years and6.0<\/mml:mn>\u00b1<\/mml:mo>3.9<\/mml:mn><\/mml:math>years. All patients underwent cataract extraction surgery. Despite ocular inflammation being controlled by topical\/systemic therapy, during adolescence (mean age of appearance\/diagnosis:12.7<\/mml:mn>\u00b1<\/mml:mo>3.9<\/mml:mn><\/mml:math>years) patients developed severe unilateral macular edema. OCT revealed massive macular thickening (range from 550\u2009\u03bc<\/jats:italic>m to 1214\u2009\u03bc<\/jats:italic>m).Conclusions<\/jats:italic>. Macular edema appeared in female adolescent patients in eyes with long-dating CAU submitted to cataract surgery. In such patients, in presence of age-related microvascular changes due to the enhancer effect of sex hormones, cataract extraction should be a factor triggering the retinal complication.<\/jats:p>","DOI":"10.1155\/2013\/803989","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T17:01:58Z","timestamp":1376931718000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Severe Macular Edema in Patients with Juvenile Idiopathic Arthritis-Related Uveitis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maria Pia","family":"Paroli","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Spinucci","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-6491","authenticated-orcid":true,"given":"Irene","family":"Abicca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Sapia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Immunovirology Service, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Spadea","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, University of L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903311999"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3282f03d2e"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1159\/000096225"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.1.51"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802187466"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.025"},{"issue":"6","key":"7","first-page":"227","volume":"25","year":"1993","journal-title":"Annals of Ophthalmology"},{"key":"8","first-page":"923","volume":"10","year":"2004","journal-title":"Molecular Vision"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700713"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/803989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/803989.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2013\/803989.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T21:32:17Z","timestamp":1471555937000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2013\/803989\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":9,"alternative-id":["803989","803989"],"URL":"https:\/\/doi.org\/10.1155\/2013\/803989","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"value":"2090-6722","type":"print"},{"value":"2090-6730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}