{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:18:47Z","timestamp":1781522327028,"version":"3.54.1"},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Science and Technology Major Project of China","award":["2007BAI20B092"],"award-info":[{"award-number":["2007BAI20B092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chinese herbal medicine (CHM) has been used in China and elsewhere to treat patients with functional dyspepsia (FD). However, controlled studies supporting the efficacy of such treatment are lacking.<jats:italic>Objective<\/jats:italic>. To assess the efficacy and safety of modified Ban xia xie xin decoction in patients with FD of cold and heat in complexity syndrome.<jats:italic>Methods<\/jats:italic>. We performed a randomized, double-blind, placebo-controlled trial involving patients from five centers. Patients with FD of cold and heat in complexity syndrome<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>101<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>were randomly assigned to groups given either CHM modified Ban Xia Xie Xin decoction or placebo in a 2\u2009:\u20091 ratio. Herbal or placebo granules were dissolved in 300\u2009mL of boiled water cooled to 70\u00b0C. Patients in both groups were administered 150\u2009mL (50\u00b0C) twice daily. The trial included a 4-week treatment period and a 4-week followup period. The primary outcomes were dyspepsia symptom scores, measured by the total dyspepsia symptom scale and the single dyspepsia symptom scale at weeks 0, 1, 2, 3, 4, and 8.<jats:italic>Results<\/jats:italic>. Compared with patients in the placebo group, patients in the CHM group showed significant improvements according to the total and single dyspepsia symptom scores obtained from patients<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>and investigators<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>.<jats:italic>Conclusions<\/jats:italic>. CHM modified Ban Xia Xie Xin decoction appears to offer symptomatic improvement in patients with FD of cold and heat in complexity syndrome.<jats:italic>Trial Registration<\/jats:italic>. Chinese Clinical Trial Registry (ChiCTR): ChiCTR-TRC-10001074.<\/jats:p>","DOI":"10.1155\/2013\/812143","type":"journal-article","created":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T21:00:49Z","timestamp":1363554049000},"page":"1-8","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2013","author":[{"given":"Luqing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguan Back Street, Dongcheng District, Beijing 100010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguan Back Street, Dongcheng District, Beijing 100010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguan Back Street, Dongcheng District, Beijing 100010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Guangdong University of Traditional Chinese Medicine, No. 111 Dade Street, Baiyun District, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, No. 155 Hanzhong Street, Jianye District, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Xuanwu Hospital of Traditional Chinese Medicine, No. 8 Wanming Street, Xicheng District, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguan Back Street, Dongcheng District, Beijing 100010, 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