{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:52:31Z","timestamp":1789609951362,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI026328"],"award-info":[{"award-number":["AI026328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We have identified a CD8<jats:sup>+<\/jats:sup>CXCR5<jats:sup>+<\/jats:sup>T cell that prevents the development of oviduct dilation following<jats:italic>C. muridarum<\/jats:italic>genital infection. Phenotypic studies show that CD8<jats:sup>+<\/jats:sup>CXCR5<jats:sup>+<\/jats:sup>cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin).<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>C<\/mml:mi><mml:mi>x<\/mml:mi><mml:mi>c<\/mml:mi><mml:mi>r<\/mml:mi><mml:msup><mml:mrow><mml:mn>5<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mo>\/<\/mml:mo><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>mice have significantly lower numbers of CD8<jats:sup>+<\/jats:sup>cells and lack the CD8<jats:sup>+<\/jats:sup>CXCR5<jats:sup>+<\/jats:sup>population while the total number of CD4<jats:sup>+<\/jats:sup>cells is equivalent between mouse strains. The transfer of CD8<jats:sup>+<\/jats:sup>splenocytes from WT mice reduces the oviduct dilation seen in<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>C<\/mml:mi><mml:mi>x<\/mml:mi><mml:mi>c<\/mml:mi><mml:mi>r<\/mml:mi><mml:msup><mml:mrow><mml:mn>5<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mo>\/<\/mml:mo><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:math>mice following<jats:italic>C. muridarum<\/jats:italic>infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology.<\/jats:p>","DOI":"10.1155\/2013\/813238","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T16:28:27Z","timestamp":1357835307000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["CD8<sup>+<\/sup>CXCR5<sup>+<\/sup>T Cells Regulate Pathology in the Genital Tract"],"prefix":"10.1155","volume":"2013","author":[{"given":"Janina","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl I.","family":"Champion","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, 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