{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:06:19Z","timestamp":1783029979281,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007774","name":"Instituto de Ciencia y Tecnolog\u00eda del Distrito Federal","doi-asserted-by":"publisher","award":["3410766"],"award-info":[{"award-number":["3410766"]}],"id":[{"id":"10.13039\/100007774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>We investigated the anti-inflammatory activity of<jats:italic>Senecio salignus<\/jats:italic>. This medicinal plant is often used in Mexico for the treatment of fever and rheumatism. Chloroform and methanol extracts of the plant were tested on 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced edema in mice ears. The methanol extract of the plant inhibited edema by<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>36<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.4<\/mml:mn><\/mml:math>% compared with the control, while the chloroform extract exhibited an even greater level of inhibition (64.1%). The chloroform extract was then fractionated, and the composition of the active fraction was determined by GC-MS. The anti-inflammatory activity of this fraction was then tested on TPA-induced ear edema in mice, and we found that the active fraction could inhibit edema by 46.9%. The anti-inflammatory effect of the fraction was also tested on carrageenan-induced paw edema in rats at doses of 100\u2009mg\/kg; a<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>58.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.8<\/mml:mn><\/mml:math>% reduction of the edema was observed 4\u2009h after administration of carrageenan, and the effect was maintained for 5\u2009h.<\/jats:p>","DOI":"10.1155\/2013\/814693","type":"journal-article","created":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T17:00:34Z","timestamp":1365958834000},"page":"1-4","source":"Crossref","is-referenced-by-count":8,"title":["Anti-Inflammatory Activity and Composition of<i>Senecio salignus<\/i>Kunth"],"prefix":"10.1155","volume":"2013","author":[{"given":"Cuauhtemoc","family":"P\u00e9rez Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma Metropolitana-Xochimilco, AP 23-181, 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