{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:30:13Z","timestamp":1765279813701,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fisher and Paykel Healthcare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The aim of this investigation was to examine the alterations in the peritoneum after cold dry CO<jats:sub>2<\/jats:sub>, heated dry CO<jats:sub>2<\/jats:sub>, and humidified heated CO<jats:sub>2<\/jats:sub>at pressures equivalent to intraperitoneal pressures used in human laparoscopy.<jats:italic>Methods<\/jats:italic>. Eighteen rats were divided into 4 treatment groups\u2014group 1: untreated control; group 2: insufflation with cold dry CO<jats:sub>2<\/jats:sub>; group 3: insufflation with heated, dry CO<jats:sub>2<\/jats:sub>; group 4: insufflation with heated and humidified CO<jats:sub>2<\/jats:sub>. The abdomen was insufflated to 5\u2009mm\/Hg (flow rate 50\u2009mL\/min) for 2\u2009h. Twelve hours later, tissue samples were collected for analysis by light microscopy (LM) and scanning electron microscopy (SEM).<jats:italic>Results<\/jats:italic>. Group 1: no abnormalities were detected. Group 2: specimens revealed an inflammatory response with loss of mesothelium and mesothelial cell nuclei showing lytic change. Cells were rounded with some areas of cell flattening and separation. Group 3: some animals showed little or no alteration, while others had a mild inflammatory response. Mesothelial cells were rounded and showed crenation on the exposed surface. Group 4: specimens showed little change from the control group.<jats:italic>Conclusions<\/jats:italic>. The LM results indicate that insufflations with heated, humidified CO<jats:sub>2<\/jats:sub>are the least likely to induce mesothelial damage.<\/jats:p>","DOI":"10.1155\/2013\/816283","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T02:27:39Z","timestamp":1372127259000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["The Effects of Insufflation Conditions on Rat Mesothelium"],"prefix":"10.1155","volume":"2013","author":[{"given":"Andrew K.","family":"Davey","sequence":"first","affiliation":[{"name":"Research Centre for the Molecular Basis of Disease, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia"},{"name":"School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5001, 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