{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:20:53Z","timestamp":1767165653497,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"\n Purpose<\/jats:italic>\n . To evaluate the treatment effect and side effect of Shenqi Fuzheng Injection (SFI) on alleviating transient worsening of myasthenia gravis (MG) symptoms caused by high-dose steroids pulse therapy.\n Methods<\/jats:italic>\n . Sixty-six consecutive patients with MG were randomly divided into two groups: the treatment group treated with SFI and methylprednisolone pulse therapy (MPT) and the control group treated with MPT alone. The severity of MG before, during, and after MPT and the duration of transient worsening (TW) were evaluated and compared with the clinical absolute scoring (AS) and relative scoring (RS) system.\n Results<\/jats:italic>\n . Twenty-nine patients experienced TW in each group. At TW, the AS was significantly increased (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.000<\/mml:mn>\n <\/mml:math>\n ) in both groups compared with baseline data, with the AS increase in the treatment group (16.8\u2009\u00b1\u20092) significantly smaller (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.05<\/mml:mn>\n <\/mml:math>\n ) than in the control group (24.9\u2009\u00b1\u20092.5). At the end of the treatment course, the AS for the treatment group was significantly decreased (7.5\u2009\u00b1\u20090.9) compared with at TW, although no significant difference compared with the control (9.7\u2009\u00b1\u20091.1). The TW lasted 1\u20136 days (mean 3.7) for the treatment group, significantly shorter (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.05<\/mml:mn>\n <\/mml:math>\n ) than 2\u201312 days (mean 7.8) for the control. The RS for the treatment group at the end of treatment was 43.8%\u2013100% (mean 76.8%\u2009\u00b1\u20092.6%), significantly better than the control group: 33.3%\u2013100% (mean 67.2\u2009\u00b1\u20093.6%). Slight side effects (18.75%) included maldigestion and rash in the treatment group.\n Conclusion<\/jats:italic>\n . SFI has a better treatment effect and few side effects and can alleviate the severity and shorten the duration of the transient worsening of MG during steroids pulse therapy.\n <\/jats:p>\n \n \n Erratum to \u201cShenqi Fuzheng Injection Alleviates the Transient Worsening Caused by Steroids Pulse Therapy in Treating Myasthenia Gravis\u201d<\/jats:bold>\n \n <\/jats:p>","DOI":"10.1155\/2013\/816829","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T17:03:23Z","timestamp":1384967003000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Shenqi Fuzheng Injection Alleviates the Transient Worsening Caused by Steroids Pulse Therapy in Treating Myasthenia Gravis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Guo-Yan","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Oncology, Shijiazhuang First Hospital and Hebei Provincial Hospital of Myasthenia Gravis, 36 Fanxi Road, Shijiazhuang, Hebei 050011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shijiazhuang First Hospital and Hebei Provincial Hospital of Myasthenia Gravis, 36 Fanxi Road, Shijiazhuang, Hebei 050011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-0737","authenticated-orcid":true,"given":"Bu-Lang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shijiazhuang First Hospital and Hebei Provincial Hospital of Myasthenia Gravis, 36 Fanxi Road, Shijiazhuang, Hebei 050011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.4.173"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302507"},{"issue":"12","key":"3","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1212\/01.WNL.0000098887.24618.A0","volume":"61","year":"2003","journal-title":"Neurology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01476.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2005.12.041"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.9.3.351"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1212\/WNL.36.5.729","volume":"36","year":"1986","journal-title":"Neurology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-137"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1021\/jf0202279"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.065"},{"key":"11","first-page":"89","volume":"25","year":"2005","journal-title":"Chinese Journal of Clinical Medicine"},{"key":"12","first-page":"87","volume":"30","year":"1997","journal-title":"Zhonghua Shen Jing Ke Za Zhi"},{"key":"13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","volume":"44","year":"2013","journal-title":"Clinical Reviews in Allergy & Immunology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2010.531010"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02110.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0857"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440106"},{"issue":"2","key":"19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJM200101113440206","volume":"344","year":"2001","journal-title":"The New England Journal of Medicine"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81107-1"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2008.11.002"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2006.06.007"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1749-8546-7-16","volume":"7","year":"2012","journal-title":"Chinese Medicine"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel030"},{"key":"25","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3760\/cma.j.issn.0366-6999.20121844","volume":"126","year":"2013","journal-title":"Chinese Medical Journal"}],"updated-by":[{"DOI":"10.1155\/2014\/626972","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/816829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/816829.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/816829.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T23:39:35Z","timestamp":1716161975000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/816829\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"alternative-id":["816829","816829"],"URL":"https:\/\/doi.org\/10.1155\/2013\/816829","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}