{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:26:06Z","timestamp":1788315966310,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012-0004337"],"award-info":[{"award-number":["2012-0004337"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["B120069"],"award-info":[{"award-number":["B120069"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["PJ009622"],"award-info":[{"award-number":["PJ009622"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2012-0004337"],"award-info":[{"award-number":["2012-0004337"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["B120069"],"award-info":[{"award-number":["B120069"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["PJ009622"],"award-info":[{"award-number":["PJ009622"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rural Development Administration, Republic of Korea","award":["2012-0004337"],"award-info":[{"award-number":["2012-0004337"]}]},{"name":"Rural Development Administration, Republic of Korea","award":["B120069"],"award-info":[{"award-number":["B120069"]}]},{"name":"Rural Development Administration, Republic of Korea","award":["PJ009622"],"award-info":[{"award-number":["PJ009622"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Sophoraflavanone B (SPF-B), a known prenylated flavonoid, was isolated from the roots of\n                    <jats:italic>Desmodium caudatum<\/jats:italic>\n                    . The aim of this study was to determine the antimicrobial synergism of SPF-B combined with antibiotics against methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA). MRSA, a multidrug-resistant pathogen, causes both hospital- and community-acquired infections worldwide. The antimicrobial activity of SPF-B was assessed by the broth microdilution method, checkerboard dilution test, and time-kill curve assay. The MIC of SPF-B for 7 strains of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ranges from 15.6 to 31.25\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL determined. In the checkerboard method, the combinations of SPF-B with antibiotics had a synergistic effect; SPF-B markedly reduced the MICs of the\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -lactam antibiotics: ampicillin (AMP) and oxacillin (OXI); aminoglycosides gentamicin (GET); quinolones ciprofloxacin (CIP) and norfloxacin (NOR) against MRSA. The time-kill curves assay showed that a combined SPF-B and selected antibiotics treatment reduced the bacterial counts below the lowest detectable limit after 24\u2009h. These data suggest that the antibacterial activity of SPF-B against MRSA can be effectively increased through its combination with three groups of antibiotics (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -lactams, aminoglycosides, and quinolones). Our research can be a valuable and significant source for the development of a new antibacterial drug with low MRSA resistance.\n                  <\/jats:p>","DOI":"10.1155\/2013\/823794","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T05:19:56Z","timestamp":1389244796000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Combination Therapy of Sophoraflavanone B against MRSA:\n                    <i>In Vitro<\/i>\n                    Synergy Testing"],"prefix":"10.1155","volume":"2013","author":[{"given":"Su-Hyun","family":"Mun","sequence":"first","affiliation":[{"name":"BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok-Hwa","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Ki","family":"Joung","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Gi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Seob","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 369-873, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Woo","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 369-873, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Sup","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 369-873, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 369-873, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yeul","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkang University, 344-2 Sinyong-dong, Iksan, Chonbuk 570-749, Republic of 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