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In the context of autoimmune diseases defined by B and\/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only producing autoantibodies but also functioning as antigen-presenting cells (APC) and as a source of cytokines. In this paper, we describe B lymphocyte functions in autoimmunity and autoimmune diseases with a special focus on their abnormalities in systemic lupus erythematosus.<\/jats:p>","DOI":"10.1155\/2013\/827254","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T21:12:39Z","timestamp":1380229959000},"page":"1-17","source":"Crossref","is-referenced-by-count":44,"title":["B Lymphocytes: Development, Tolerance, and Their Role in Autoimmunity\u2014Focus on Systemic Lupus Erythematosus"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4218","authenticated-orcid":true,"given":"Gabriel J.","family":"Tob\u00f3n","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Fundaci\u00f3n Valle del Lili, ICESI University School of Medicine, Cra 98 No. 18-49, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge 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