{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:02:13Z","timestamp":1791194533917,"version":"4.1.0"},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with<jats:sup>90<\/jats:sup>Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2\u201350.6). Outcomes were: complete response (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:math>), partial response (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>13<\/mml:mn><\/mml:mrow><\/mml:math>), stable disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:math>), and progressive disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:math>) giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare<jats:sup>90<\/jats:sup>Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.<\/jats:p>","DOI":"10.1155\/2013\/827649","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T14:47:56Z","timestamp":1361198876000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results"],"prefix":"10.1155","volume":"2013","author":[{"given":"M.","family":"Pracht","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"},{"name":"University of Rennes 1, 35043 Rennes, France"},{"name":"INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Edeline","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"},{"name":"University of Rennes 1, 35043 Rennes, France"},{"name":"INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"},{"name":"University of Rennes 1, 35043 Rennes, France"},{"name":"INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Latournerie","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Audrain","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Rolland","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Eug\u00e8ne Marquis, CS 44229, 35042 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"University of Rennes 1, 35043 Rennes, France"},{"name":"INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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