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Also, the increasingly higher resistance to conventional antibiotics has become a global public health issue, and the need for new antibiotics has stimulated interest in finding and synthesizing new antimicrobial peptides, which may also be used as chemotherapeutic agents. Relying on the literature, the purpose of our<jats:italic>in vitro<\/jats:italic>research was to assess the tumoricidal potential of magainin II on a series of tumour cell lines, namely, MDA-MB-231 (breast adenocarcinoma) and M14K (human mesothelioma). The experimental results of our study revealed that the cytotoxic effects of magainin II depend on its concentration. Its efficiency is significant at 120\u2009<jats:italic>\u03bc<\/jats:italic>M concentrations, and, although it is much lower, it persists even at 60\u2009<jats:italic>\u03bc<\/jats:italic>M concentrations. The effects were insignificant at 30\u2009<jats:italic>\u03bc<\/jats:italic>M concentrations. In our experimental research, the tumoricidal effect of magainin II was not significantly dependent on the type of tumour cell line used.<\/jats:p>","DOI":"10.1155\/2013\/831709","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T06:20:34Z","timestamp":1382595634000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["The Cytotoxic Effect of Magainin II on the MDA-MB-231 and M14K Tumour Cell Lines"],"prefix":"10.1155","volume":"2013","author":[{"given":"Radu","family":"Anghel","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Jitaru","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Regional Institute of Oncology Iasi, University of Medicine and Pharmacy \u201cGrigore T. 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