{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:27:42Z","timestamp":1751448462352},"reference-count":5,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Type 2N Von Willebrand's disease (2N VWD) is a rare, recessively inherited bleeding disorder, comprising 1-2% of all VWD patients, usually manifesting as a mild bleeding diathesis. Treatment includes desmopressin (DDAVP) or intermediate purity plasma-derived FVIII concentrates containing residual VWF. We present a case of a 75-year-old gentleman, incidentally diagnosed with type 2N VWD in 2002 on routine blood testing before surgery with an ISTH bleeding score of 1-2, who was treated with recombinant FVIII preoperatively.<\/jats:p>","DOI":"10.1155\/2013\/837906","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T16:04:19Z","timestamp":1359993859000},"page":"1-2","source":"Crossref","is-referenced-by-count":1,"title":["Perioperative Management of Type 2N Von Willebrand\u2019s Disease with Recombinant Factor VIII in a Patient Undergoing Knee-Replacement Surgery"],"prefix":"10.1155","volume":"2013","author":[{"given":"Srivasavi","family":"Dukka","sequence":"first","affiliation":[{"name":"Department of Haematology, Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Castle Road, Cottingham, East Riding of Yorkshire HU16 5JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David John","family":"Allsup","sequence":"additional","affiliation":[{"name":"Department of Haematology, Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Castle Road, Cottingham, East Riding of Yorkshire HU16 5JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01713.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2516.2004.00979.x","volume":"10","year":"2004","journal-title":"Haemophilia"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00428.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01435.x"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/837906.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/837906.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2013\/837906.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T02:55:52Z","timestamp":1498013752000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2013\/837906\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":5,"alternative-id":["837906","837906"],"URL":"https:\/\/doi.org\/10.1155\/2013\/837906","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}