{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:25:24Z","timestamp":1773235524575,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PRONEX\/Funda\u00e7\u00e3o Arauc\u00e1ria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Stryphnodendron adstringens<\/jats:italic>has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of<jats:italic>S. adstringens<\/jats:italic>in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD<jats:sub>50<\/jats:sub>of 3.015\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mtext>mg<\/mml:mtext><mml:mo>\u00b7<\/mml:mo><mml:msup><mml:mrow><mml:mtext>kg<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>. In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mtext>mg<\/mml:mtext><mml:mo>\u00b7<\/mml:mo><mml:msup><mml:mrow><mml:mtext>kg<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of<jats:italic>S. adstringens<\/jats:italic>caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.<\/jats:p>","DOI":"10.1155\/2013\/841580","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T18:50:43Z","timestamp":1374173443000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of<i>Stryphnodendron adstringens<\/i>(Barbatim\u00e3o) in Rodents"],"prefix":"10.1155","volume":"2013","author":[{"given":"Marco Antonio","family":"Costa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Avenida Colombo 5790, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos","family":"Palazzo de 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