{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:57:09Z","timestamp":1791295029127,"version":"4.1.0"},"reference-count":59,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Chagas' disease (ChD), caused by the protozoa<jats:italic>Trypanosoma cruzi<\/jats:italic>(<jats:italic>T. cruzi<\/jats:italic>), was discovered and described by the Brazilian physician Carlos Chagas in 1909. After a century of original description, trypanosomiasis still brings much misery to humanity and is classified as a neglected tropical disease prevalent in underdeveloped countries, particularly in South America. It is an increasing worldwide problem due to the number of cases in endemic areas and the migration of infected subjects to more developed regions, mainly North America and Europe. Despite its importance, chronic chagas cardiomyopathy (CCC) pathophysiology is yet poorly understood, and independently of its social, clinical, and epidemiological importance, the therapeutic approach of CCC is still transposed from the knowledge acquired from other cardiomyopathies. Therefore, the objective of this review is to describe the treatment of Chagas cardiomyopathy with emphasis on its peculiarities.<\/jats:p>","DOI":"10.1155\/2013\/849504","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T21:01:57Z","timestamp":1385326917000},"page":"1-9","source":"Crossref","is-referenced-by-count":25,"title":["Treatment of Chagas Cardiomyopathy"],"prefix":"10.1155","volume":"2013","author":[{"given":"Fernando A.","family":"Botoni","sequence":"first","affiliation":[{"name":"Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"},{"name":"Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais, 30150 260 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Luiz P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Coimbra","family":"Marinho","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal de Ouro Preto, 35400 000 Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Maria Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia, Universidade Federal do Vale do Mucuri e Jequitinhonha, 39100 000 Diamantina, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Ot\u00e1vio C.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"},{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61301-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068130"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.109"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1161\/01.CIR.90.6.3098","volume":"90","year":"1994","journal-title":"Circulation"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.07.026"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00361-4"},{"issue":"2, supplement 3","key":"11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0066-782X2011001600001","volume":"97","year":"2011","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e31823efde2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.624296"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053241"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01088.x"},{"issue":"4-5","key":"12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000176409","volume":"84","year":"1994","journal-title":"Cardiology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.627265"},{"key":"16","first-page":"530","volume":"42","year":"1945","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"18","first-page":"419","volume":"29","year":"1976","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(97)00083-1"},{"issue":"7","key":"19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/oxfordjournals.eurheartj.a060301","volume":"13","year":"1992","journal-title":"European Heart Journal"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)02776-3"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00181-X"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9164(03)00504-9"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.12.017"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.07.052"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.107.744870"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.882035"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-04-0251"},{"issue":"1","key":"30","first-page":"86","volume":"76","year":"2001","journal-title":"Arquivos Brasileiros de Cardiologia"},{"issue":"4","key":"31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/0002-8703(84)90311-9","volume":"107","year":"1984","journal-title":"American Heart Journal"},{"issue":"5","key":"32","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0735-1097(86)80232-7","volume":"7","year":"1986","journal-title":"Journal of the American College of Cardiology"},{"issue":"4","key":"33","first-page":"325","volume":"57","year":"1987","journal-title":"Archivos del Instituto de Cardiolog\u00eda de M\u00e9xico"},{"issue":"2","key":"34","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1590\/S1516-31801995000200016","volume":"113","year":"1995","journal-title":"S\u00e3o Paulo Medical Journal"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00315.x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.05.040"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut011"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00377.x"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00954.x"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02278.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-009-9433-4"},{"issue":"1","key":"42","first-page":"593","volume":"6","year":"2010","journal-title":"Vascular Health and Risk Management"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.2174\/157340308785160534"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2012.10.029"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03381.x"},{"issue":"2","key":"46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/cclm-2012-0316","volume":"51","year":"2013","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.05.006"},{"key":"48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S0074-02762009000900043","volume":"104","year":"2009","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/484358"},{"issue":"2","key":"50","first-page":"159","volume":"87","year":"2006","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-2"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.067785"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.002"},{"key":"54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1590\/S0074-02762009000900029","volume":"104","year":"2009","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.10.023"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00372.x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq123"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq022"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2009.01081.x"},{"issue":"6","key":"60","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S0074-02762011000600001","volume":"106","year":"2011","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04128-1"},{"key":"64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4269\/ajtmh.1998.59.526","volume":"59","year":"1998","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.04.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/849504.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/849504.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/849504.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T08:21:43Z","timestamp":1647505303000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/849504\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":59,"alternative-id":["849504","849504"],"URL":"https:\/\/doi.org\/10.1155\/2013\/849504","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}